T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines

William Agace, J M Higgins, B Sadasivan, M B Brenner, C M Parker

Research output: Contribution to journalReview articlepeer-review

130 Citations (SciVal)


The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.
Original languageEnglish
Pages (from-to)563-568
JournalCurrent Opinion in Cell Biology
Issue number5
Publication statusPublished - 2000

Subject classification (UKÄ)

  • Immunology in the medical area


  • T cell
  • CD103
  • Lymphocyte
  • Chemokine
  • Homing
  • Epithelium
  • Cell adhesion
  • Cell adhesion molecule
  • Chemokine receptor
  • Alpha E


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