T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines

William Agace, J M Higgins, B Sadasivan, M B Brenner, C M Parker

    Research output: Contribution to journalReview articlepeer-review


    The epithelia are the avascular layers of cells that cover the environment-exposed surfaces of the body. It appears that T cells localize to selected sites in or adjacent to epithelia via the selective expression of adhesion molecules and chemokine receptors on T cells. These bind to counter-receptors and to chemokines expressed by epithelial cells. Recently, there has been an advance in our understanding of the interaction of the alpha(Ebeta7) integrin with its epithelial cell ligand, E-cadherin. In addition, a new adhesion molecule has been identified on non-intestinal epithelial cells, termed lymphocyte-endothelial-epithelial-cell adhesion molecule (LEEP-CAM). Finally, there have been advances in our understanding of the role of skin- or gut-epithelia-derived chemokines in regulating activated T cell homing to these sites.
    Original languageEnglish
    Pages (from-to)563-568
    JournalCurrent Opinion in Cell Biology
    Issue number5
    Publication statusPublished - 2000

    Subject classification (UKÄ)

    • Immunology in the medical area

    Free keywords

    • T cell
    • CD103
    • Lymphocyte
    • Chemokine
    • Homing
    • Epithelium
    • Cell adhesion
    • Cell adhesion molecule
    • Chemokine receptor
    • Alpha E


    Dive into the research topics of 'T-lymphocyte-epithelial-cell interactions: integrin alpha(E)(CD103)beta(7), LEEP-CAM and chemokines'. Together they form a unique fingerprint.

    Cite this