TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

Isabel Drake; Peter Wallström; George Hindy; Ulrika Ericson; Bo Gullberg; Anders Bjartell; Emily Sonestedt; Marju Orho-Melander; Elisabet Wirfält

doi:10.1002/pros.22832

TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

Isabel Drake, Peter Wallström, George Hindy, Ulrika Ericson, Bo Gullberg, Anders Bjartell, Emily Sonestedt, Marju Orho-Melander, Elisabet Wirfält

Research output: Contribution to journal › Article › peer-review

Abstract

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

Original language	English
Pages (from-to)	1161-1170
Journal	The Prostate
Volume	74
Issue number	12
DOIs	https://doi.org/10.1002/pros.22832
Publication status	Published - 2014

Subject classification (UKÄ)

Obstetrics, Gynecology and Reproductive Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1002/pros.22832

http://www.ncbi.nlm.nih.gov/pubmed/24961829?dopt=Abstract

1 Doctoral Thesis (compilation)

Diabetes mellitus and risk of prostate cancer - A focus on shared risk factors and survivor bias
Drake, I., 2014, Department of Clinical Sciences, Lund University. 106 p.
Research output: Thesis › Doctoral Thesis (compilation)

Cite this

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title = "TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.",

abstract = "Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.",

author = "Isabel Drake and Peter Wallstr{\"o}m and George Hindy and Ulrika Ericson and Bo Gullberg and Anders Bjartell and Emily Sonestedt and Marju Orho-Melander and Elisabet Wirf{\"a}lt",

year = "2014",

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pages = "1161--1170",

journal = "The Prostate",

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publisher = "John Wiley & Sons Inc.",

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TY - JOUR

T1 - TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

AU - Drake, Isabel

AU - Wallström, Peter

AU - Hindy, George

AU - Ericson, Ulrika

AU - Gullberg, Bo

AU - Bjartell, Anders

AU - Sonestedt, Emily

AU - Orho-Melander, Marju

AU - Wirfält, Elisabet

PY - 2014

Y1 - 2014

N2 - Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

AB - Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

U2 - 10.1002/pros.22832

DO - 10.1002/pros.22832

M3 - Article

C2 - 24961829

SN - 0270-4137

VL - 74

SP - 1161

EP - 1170

JO - The Prostate

JF - The Prostate

IS - 12

ER -

TCF7L2 type 2 diabetes risk variant, lifestyle factors, and incidence of prostate cancer.

Abstract

Subject classification (UKÄ)

UN SDGs

Access to Document

Fingerprint

Research output

Diabetes mellitus and risk of prostate cancer - A focus on shared risk factors and survivor bias

Cite this