TY - JOUR
T1 - Telomerase activation as a possible mechanism of action for psychopharmacological interventions.
AU - Bersani, Francesco S
AU - Lindqvist, Daniel
AU - Mellon, Synthia H
AU - Penninx, Brenda W J H
AU - Verhoeven, Josine E
AU - Révész, Dóra
AU - Reus, Victor I
AU - Wolkowitz, Owen M
PY - 2015
Y1 - 2015
N2 - Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions.
AB - Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/β-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions.
U2 - 10.1016/j.drudis.2015.06.016
DO - 10.1016/j.drudis.2015.06.016
M3 - Review article
C2 - 26166813
SN - 1878-5832
VL - 20
SP - 1305
EP - 1309
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 11
ER -
