TY - JOUR
T1 - Temporal development of the humoral immune response to surface antigens of Moraxella catarrhalis in young infants
AU - Verhaegh, Suzanne J. C.
AU - de Vogel, Corne P.
AU - Riesbeck, Kristian
AU - Lafontaine, Eric R.
AU - Murphy, Timothy F.
AU - Verbrugh, Henri A.
AU - Jaddoe, Vincent W. V.
AU - Hofman, Albert
AU - Moll, Henriette A.
AU - van Belkum, Alex
AU - Hays, John P.
PY - 2011
Y1 - 2011
N2 - The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag(385-863), MID764-913, MID962-1200, UspA1(557-704) and UspA2(165-318) in cord blood compared to 6 months of age (P <= 0.001). This was a most likely a consequence of maternal transmission of antigen-specific IgG to newborn babies, possibly indicating a future role for these 3 surface antigens in the development of an effective humoral immune response to M. catarrhalis. Finally, at 2 years of age, the levels of antigen-specific IgG still remained far below that obtained from cord blood samples, indicating that the immune response to M. catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1,UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events. (C) 2011 Elsevier Ltd. All rights reserved.
AB - The primary Moraxella catarrha/is-specific humoral immune response, and its association with nasopharyngeal colonization, was studied in a cohort of infants from birth to 2 years of age. Results indicated that the levels of antigen-specific IgG, IgA and IgM showed extensive inter-individual variability over time, with IgM and IgA levels to all 9 recombinant domains, from 7 different OMPs, being relatively low throughout the study period. In contrast, the level of antigen-specific IgG was significantly higher for the recombinant domains Hag(385-863), MID764-913, MID962-1200, UspA1(557-704) and UspA2(165-318) in cord blood compared to 6 months of age (P <= 0.001). This was a most likely a consequence of maternal transmission of antigen-specific IgG to newborn babies, possibly indicating a future role for these 3 surface antigens in the development of an effective humoral immune response to M. catarrhalis. Finally, at 2 years of age, the levels of antigen-specific IgG still remained far below that obtained from cord blood samples, indicating that the immune response to M. catarrhalis has not matured at 2 years of age. We provide evidence that a humoral antibody response to OMPs UspA1,UspA2 and Hag/MID may play a role in the immune response to community acquired M. catarrhalis colonization events. (C) 2011 Elsevier Ltd. All rights reserved.
KW - Moraxella catarrhalis
KW - Colonization
KW - Immune response
KW - Surface antigens
KW - Vaccine
KW - Children
U2 - 10.1016/j.vaccine.2011.06.019
DO - 10.1016/j.vaccine.2011.06.019
M3 - Article
C2 - 21704103
SN - 1873-2518
VL - 29
SP - 5603
EP - 5610
JO - Vaccine
JF - Vaccine
IS - 34
ER -
