Ten-a overexpression causes abnormal pattern in the Drosophila compound eye

Lertluk Ngernsiri, Nora Fascetti, Suppaluk Romratanapan, Stefan Baumgartner

Research output: Contribution to journalArticlepeer-review

1 Citation (SciVal)

Abstract

Abstract Ten-a is one of the two Drosophila proteins that belong to the Ten M protein family. This protein is a type II transmembrane protein and is expressed mainly in the embryonic CNS, in the larval eye imaginal disc and in the compound eye of the pupa. Here, we investigate the role of ten-a during development of the compound eye by using the Gal4/UAS system to induce ten-a overexpression in the developing eye. We found that overexpression of ten-a can perturb eye development during all stages examined. In an early stage, overexpression of ten-a in eye primordial cells caused small and rough eyes and interfered with photoreceptor cell recruitment, resulting in some ommatidia having fewer or extra photoreceptor cells. Conversely, ten-a overexpression during ommatidial formation caused severe eye defects due to absence of many cellular components. Interestingly, overexpression of ten-a in the late stage developing ommatidial cluster affected the number of pigment cells, caused cone cells proliferation in many ommatidia, and caused some photoreceptor cell defects. These results suggest that ten-a may be a novel gene required for normal eye morphogenesis.

Original languageEnglish
Pages (from-to)355-364
JournalInsect science
Volume13
Issue number5
DOIs
Publication statusPublished - 2006 Jan 1

Subject classification (UKÄ)

  • Developmental Biology

Keywords

  • Compound eye
  • Drosophila
  • Gal4/UAS system
  • Ommatidia
  • Ten-a

Fingerprint

Dive into the research topics of 'Ten-a overexpression causes abnormal pattern in the Drosophila compound eye'. Together they form a unique fingerprint.

Cite this