Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors

Markus Nilsson; Filip Szczepankiewicz; Jan Brabec; Marie Taylor; Carl Fredrik Westin; Alexandra Golby; Danielle van Westen; Pia C. Sundgren

doi:10.1002/mrm.27959

Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors

Markus Nilsson, Filip Szczepankiewicz, Jan Brabec, Marie Taylor, Carl Fredrik Westin, Alexandra Golby, Danielle van Westen, Pia C. Sundgren

Brigham and Women's Hospital / Harvard Medical School

Research output: Contribution to journal › Article › peer-review

Abstract

Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MK_A) and isotropic kurtosis (MK_I), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MK_A = 0.29 ± 0.06 vs. 0.45 ± 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MK_I = 0.57 ± 0.07) than both the glioblastomas (0.44 ± 0.06, P < 0.001) and meningiomas (0.46 ± 0.06, P = 0.03). Conclusion: Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.

Original language	English
Pages (from-to)	608-620
Journal	Magnetic Resonance in Medicine
Volume	83
Issue number	2
Early online date	2019
DOIs	https://doi.org/10.1002/mrm.27959
Publication status	Published - 2020

Subject classification (UKÄ)

Radiology, Nuclear Medicine and Medical Imaging
Other Physics Topics

Keywords

diffusion MRI
microscopic anisotropy
tumor heterogeneity

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10.1002/mrm.27959Licence: CC BY-NC

1 Doctoral Thesis (compilation)

Applications of diffusion MRI: Tensor-valued encoding, time-dependent diffusion, and histological validation
Brabec, J., 2022 Oct 7, 1 ed. Lund, Sweden: Lund University, Faculty of Science, Department of Medical Radiation Physics. 180 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors",

abstract = "Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MKA) and isotropic kurtosis (MKI), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MKA = 0.29 ± 0.06 vs. 0.45 ± 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MKI = 0.57 ± 0.07) than both the glioblastomas (0.44 ± 0.06, P < 0.001) and meningiomas (0.46 ± 0.06, P = 0.03). Conclusion: Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.",

keywords = "diffusion MRI, microscopic anisotropy, tumor heterogeneity",

author = "Markus Nilsson and Filip Szczepankiewicz and Jan Brabec and Marie Taylor and Westin, {Carl Fredrik} and Alexandra Golby and {van Westen}, Danielle and Sundgren, {Pia C.}",

year = "2020",

doi = "10.1002/mrm.27959",

language = "English",

volume = "83",

pages = "608--620",

journal = "Magnetic Resonance in Medicine",

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T1 - Tensor-valued diffusion MRI in under 3 minutes

T2 - an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors

AU - Nilsson, Markus

AU - Szczepankiewicz, Filip

AU - Brabec, Jan

AU - Taylor, Marie

AU - Westin, Carl Fredrik

AU - Golby, Alexandra

AU - van Westen, Danielle

AU - Sundgren, Pia C.

PY - 2020

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N2 - Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MKA) and isotropic kurtosis (MKI), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MKA = 0.29 ± 0.06 vs. 0.45 ± 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MKI = 0.57 ± 0.07) than both the glioblastomas (0.44 ± 0.06, P < 0.001) and meningiomas (0.46 ± 0.06, P = 0.03). Conclusion: Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.

AB - Purpose: To evaluate the feasibility of a 3-minutes protocol for assessment of the microscopic anisotropy and tissue heterogeneity based on tensor-valued diffusion MRI in a wide range of intracranial tumors. Methods: B-tensor encoding was performed in 42 patients with intracranial tumors (gliomas, meningiomas, adenomas, and metastases). Microscopic anisotropy and tissue heterogeneity were evaluated by estimating the anisotropic kurtosis (MKA) and isotropic kurtosis (MKI), respectively. An extensive imaging protocol was compared with a 3-minutes protocol. Results: The fast imaging protocol yielded parameters with characteristics in terms of bias and precision similar to the full protocol. Glioblastomas had lower microscopic anisotropy than meningiomas (MKA = 0.29 ± 0.06 vs. 0.45 ± 0.08, P = 0.003). Metastases had higher tissue heterogeneity (MKI = 0.57 ± 0.07) than both the glioblastomas (0.44 ± 0.06, P < 0.001) and meningiomas (0.46 ± 0.06, P = 0.03). Conclusion: Evaluation of the microscopic anisotropy and tissue heterogeneity in intracranial tumor patients is feasible in clinically relevant times frames.

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KW - microscopic anisotropy

KW - tumor heterogeneity

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DO - 10.1002/mrm.27959

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JO - Magnetic Resonance in Medicine

JF - Magnetic Resonance in Medicine

SN - 1522-2594

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ER -

Tensor-valued diffusion MRI in under 3 minutes: an initial survey of microscopic anisotropy and tissue heterogeneity in intracranial tumors

Abstract

Subject classification (UKÄ)

Keywords

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Research output

Applications of diffusion MRI: Tensor-valued encoding, time-dependent diffusion, and histological validation

Cite this