Abstract
Background: Coronary flow reserve (CFR) is an index of coronary microcirculation. No previous reports exist on the association between testosterone levels and CFR. Therefore, the aim of the present study is to explore the association between testosterone and CFR in a group of men from the general population.
Material and Methods: The study consisted of 66 men with no history of cardiovascular disease (CVD). Clinical data included age, body mass index (BMI), smoking, alcohol consumption, family history of CVD, and systolic blood pressure (SBP) were collected. Serum levels of testosterone and HbA1c were measured, and ApoB-to-ApoA-1 ratio was calculated. CFR was assessed using transthoracic colour Doppler echocardiography. CFR was calculated as the ratio between mean hyperemic coronary flow velocity (CFV) to mean baseline CFV. The men were classified into 3 groups based on CFR : G1 (CFR ≤3), G2 (CFR = 3.1-4.0), and G3 (CFR >4).
Results: Men in G1 had significantly lower testosterone levels compared to men in G3 (12nmol/L vs. 17nmol/L; p=0.021). On the other hand, no statistically significant differences were found between men in G1 and those in G2 (12nmol/L vs. 15nmol/L; p=0.299), as well as between men in G2 and G3 (15nmol/L vs. 17nmol/L; p=0.493). Age, BMI, smoking, alcohol consumption, family history of CVD, SBP, ApoB-to-ApoA-1 ratio, and HbA1c did not differ significantly between groups. In multivariate regression analysis adjusted for the age of subjects, BMI, smoking, alcohol consumption, family history of CVD, SBP, ApoB-to-ApoA-1 ratio, and HbA1c; a significant positive association was found between testosterone and CFR (β=0.035; 95% CI=0.011, 0.069; p=0.04).
Conclusions: In men without symptomatic cardiovascular disease, there was a significant positive association between testosterone and CFR, which may indicate that testosterone levels could play a role for coronary microcirculation.
Material and Methods: The study consisted of 66 men with no history of cardiovascular disease (CVD). Clinical data included age, body mass index (BMI), smoking, alcohol consumption, family history of CVD, and systolic blood pressure (SBP) were collected. Serum levels of testosterone and HbA1c were measured, and ApoB-to-ApoA-1 ratio was calculated. CFR was assessed using transthoracic colour Doppler echocardiography. CFR was calculated as the ratio between mean hyperemic coronary flow velocity (CFV) to mean baseline CFV. The men were classified into 3 groups based on CFR : G1 (CFR ≤3), G2 (CFR = 3.1-4.0), and G3 (CFR >4).
Results: Men in G1 had significantly lower testosterone levels compared to men in G3 (12nmol/L vs. 17nmol/L; p=0.021). On the other hand, no statistically significant differences were found between men in G1 and those in G2 (12nmol/L vs. 15nmol/L; p=0.299), as well as between men in G2 and G3 (15nmol/L vs. 17nmol/L; p=0.493). Age, BMI, smoking, alcohol consumption, family history of CVD, SBP, ApoB-to-ApoA-1 ratio, and HbA1c did not differ significantly between groups. In multivariate regression analysis adjusted for the age of subjects, BMI, smoking, alcohol consumption, family history of CVD, SBP, ApoB-to-ApoA-1 ratio, and HbA1c; a significant positive association was found between testosterone and CFR (β=0.035; 95% CI=0.011, 0.069; p=0.04).
Conclusions: In men without symptomatic cardiovascular disease, there was a significant positive association between testosterone and CFR, which may indicate that testosterone levels could play a role for coronary microcirculation.
| Original language | English |
|---|---|
| Pages (from-to) | 1-4 |
| Journal | Clinical Research and Trials |
| Volume | 8 |
| DOIs | |
| Publication status | Published - 2022 |
Subject classification (UKÄ)
- Cardiology and Cardiovascular Disease
