The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Michele Compagno, Birgitta Gullstrand, Sören Jacobsen, Gro Ö Eilertsen, Jan-Åke Nilsson, Christian Lood, Andreas Jönsen, Lennart Truedsson, Gunnar Sturfelt, Anders Bengtsson

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Abstract

Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).
Original languageEnglish
Article number44
JournalArthritis Research and Therapy
Volume18
DOIs
Publication statusPublished - 2016

Subject classification (UKÄ)

  • Rheumatology and Autoimmunity

Free keywords

  • Systemic lupus erythematosus
  • Biomarkers
  • Diagnostic accuracy
  • Flow cytometry
  • Disease activity
  • Lupus nephritis

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