The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Michele Compagno; Birgitta Gullstrand; Sören Jacobsen; Gro Ö Eilertsen; Jan-Åke Nilsson; Christian Lood; Andreas Jönsen; Lennart Truedsson; Gunnar Sturfelt; Anders Bengtsson

doi:10.1186/s13075-016-0941-1

The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Michele Compagno, Birgitta Gullstrand, Sören Jacobsen, Gro Ö Eilertsen, Jan-Åke Nilsson, Christian Lood, Andreas Jönsen, Lennart Truedsson, Gunnar Sturfelt, Anders Bengtsson

Research output: Contribution to journal › Article › peer-review

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Abstract

Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).

Original language	English
Article number	44
Journal	Arthritis Research and Therapy
Volume	18
DOIs	https://doi.org/10.1186/s13075-016-0941-1
Publication status	Published - 2016

Subject classification (UKÄ)

Clinical Medicine

Free keywords

Systemic lupus erythematosus
Biomarkers
Diagnostic accuracy
Flow cytometry
Disease activity
Lupus nephritis

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10.1186/s13075-016-0941-1

BMC_Compagno_et_al

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Compagno, M., Gullstrand, B., Jacobsen, S., Eilertsen, G. Ö., Nilsson, J.-Å., Lood, C., Jönsen, A., Truedsson, L., Sturfelt, G., & Bengtsson, A. (2016). The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study. Arthritis Research and Therapy, 18, Article 44. https://doi.org/10.1186/s13075-016-0941-1

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abstract = "Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).",

keywords = "Systemic lupus erythematosus, Biomarkers, Diagnostic accuracy, Flow cytometry, Disease activity, Lupus nephritis",

author = "Michele Compagno and Birgitta Gullstrand and S{\"o}ren Jacobsen and Eilertsen, {Gro {\"O}} and Jan-{\AA}ke Nilsson and Christian Lood and Andreas J{\"o}nsen and Lennart Truedsson and Gunnar Sturfelt and Anders Bengtsson",

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Compagno, M , Gullstrand, B, Jacobsen, S, Eilertsen, GÖ, Nilsson, J-Å, Lood, C, Jönsen, A , Truedsson, L, Sturfelt, G & Bengtsson, A 2016, 'The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study', Arthritis Research and Therapy, vol. 18, 44. https://doi.org/10.1186/s13075-016-0941-1

The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study. / Compagno, Michele ; Gullstrand, Birgitta; Jacobsen, Sören et al.
In: Arthritis Research and Therapy, Vol. 18, 44, 2016.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

AU - Compagno, Michele

AU - Gullstrand, Birgitta

AU - Jacobsen, Sören

AU - Eilertsen, Gro Ö

AU - Nilsson, Jan-Åke

AU - Lood, Christian

AU - Jönsen, Andreas

AU - Truedsson, Lennart

AU - Sturfelt, Gunnar

AU - Bengtsson, Anders

PY - 2016

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N2 - Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).

AB - Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).

KW - Systemic lupus erythematosus

KW - Biomarkers

KW - Diagnostic accuracy

KW - Flow cytometry

KW - Disease activity

KW - Lupus nephritis

U2 - 10.1186/s13075-016-0941-1

DO - 10.1186/s13075-016-0941-1

M3 - Article

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SN - 1478-6362

VL - 18

JO - Arthritis Research and Therapy

JF - Arthritis Research and Therapy

M1 - 44

ER -