TY - JOUR
T1 - The association between white matter hyperintensities and executive decline in mild cognitive impairment is network dependent
AU - Jacobs, Heidi I. L.
AU - Visser, Pieter Jelle
AU - Van Boxtel, Martin P. J.
AU - Frisoni, Giovanni B.
AU - Tsolaki, Magda
AU - Papapostolou, Panagiota
AU - Nobili, Flavio
AU - Wahlund, Lars-Olof
AU - Minthon, Lennart
AU - Frolich, Lutz
AU - Hampel, Harald
AU - Soininen, Hilkka
AU - van de Pol, Laura
AU - Scheltens, Philip
AU - Tan, Frans E. S.
AU - Jolles, Jelle
AU - Verhey, Frans R. J.
PY - 2012
Y1 - 2012
N2 - White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the frontal-parietal-subcortical network were associated with decline in executive functioning. However, the frontal-subcortical network was not associated with change in executive functioning. Our results suggest that parietal WMH are a significant contributor to executive decline in MCI and that investigation of WMH in the cerebral networks supporting cognitive functions provide a new way to differentiate stable from cognitive declining MCI individuals. (C) 2012 Elsevier Inc. All rights reserved.
AB - White matter hyperintensities (WMH) in Mild Cognitive Impairment (MCI) have been associated with impaired executive functioning, although contradictory findings have been reported. The aim of this study was to examine whether WMH location influenced the relation between WMH and executive functioning in MCI participants (55-90 years) in the European multicenter memory-clinic-based DESCRIPA study, who underwent MRI scanning at baseline (N = 337). Linear mixed model analysis was performed to test the association between WMH damage in three networks (frontal-parietal, frontal-subcortical and frontal-parietal-subcortical network) and change in executive functioning over a 3-year period. WMH in the frontal-parietal and in the frontal-parietal-subcortical network were associated with decline in executive functioning. However, the frontal-subcortical network was not associated with change in executive functioning. Our results suggest that parietal WMH are a significant contributor to executive decline in MCI and that investigation of WMH in the cerebral networks supporting cognitive functions provide a new way to differentiate stable from cognitive declining MCI individuals. (C) 2012 Elsevier Inc. All rights reserved.
KW - Mild cognitive impairment
KW - White matter hyperintensities
KW - Executive
KW - function
KW - Frontoparietal circuit
U2 - 10.1016/j.neurobiolaging.2010.07.015
DO - 10.1016/j.neurobiolaging.2010.07.015
M3 - Article
C2 - 20739101
SN - 1558-1497
VL - 33
SP - 201.e1-201.e8
JO - Neurobiology of Aging
JF - Neurobiology of Aging
IS - 1
ER -