Iraqi born immigrants in Sweden have higher prevalence of metabolic diseases compared to native Swedes. Copeptin, a marker for vasopressin, is associated with increased risk of metabolic disease. In this cross-sectional population study based on the MEDIM cohort we investigated differences in copeptin levels between Iraqi and Swedish born individuals and if the association between copeptin and cardiometabolic risk markers differed by region of origin. We included 1109 Iraqi and 613 Swedish born participants (58% men, mean age 47 years). The Swedish participants had a higher concentration of copeptin compared to the Iraqi born group after age and sex adjustment (p < 0.001). This difference existed only among male individuals with the highest copeptin concentrations, i.e. belonging to copeptin quartile 4 (median (25th; 75th percentile) 20.07 (15.27;33.28) pmol/L for the Swedish born versus 15.57 (13.91;19.00) pmol/L for the Iraqi born, p < 0.001). We found a significant interaction between copeptin (continuous ln-transformed) and being born in Iraq regarding the association with plasma triglycerides (P interaction = 0.006). The association between copeptin and BMI was stronger amongst the Iraqi born individuals compared to the Swedish born. Together, this could indicate that copeptin is a more potent marker of metabolic disease among individuals born in Iraq compared to Sweden.

Original languageEnglish
Article number19651
JournalScientific Reports
Issue number1
Publication statusPublished - 2023 Dec

Bibliographical note

Funding Information:
Dr Bennet was supported by Lund University (ALF Grants 20101641, 20101837, and 162641), the Swedish Research Council (Linné Grant to LUDC 349-2006-237, Exodiab 2009-1039, 2019-00978), the Swedish foundation for Strategic Research (LUDC IRC15-0067). Dr Enhörning was supported by Grants from the Swedish Research Council (2022-01771), the Swedish Society for Medical Research (SG-22-0076), the Åke Wiberg Foundation (M21-0041), the Maggie Stephen Foundation (20202018), the Albert Påhlsson Foundation (211214SE), the Crafoord Foundation (20210603), the Swedish Society of Medicine (SLS-959724), the Swedish Heart and Lung Foundation (20200126), Skåne University Hospital and Region Skåne (2020-0358). Dr Pikkemaat was supported by Lund University (ALF Grant YF0042). The authors would like to thank statistician Mats Pihlsgård, Ph.D., for the help to conduct the statistical analyses.

Publisher Copyright:
© 2023, The Author(s).

Subject classification (UKÄ)

  • Public Health, Global Health, Social Medicine and Epidemiology


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