The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Helena Fritz; Anna Gustafsson; Börje Ljungberg; Yvonne Ceder; Håkan Axelson; Björn Dahlbäck

doi:10.1371/journal.pone.0135991

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Helena Fritz, Anna Gustafsson, Börje Ljungberg, Yvonne Ceder, Håkan Axelson, Björn Dahlbäck

Research output: Contribution to journal › Article › peer-review

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Abstract

High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

Original language	English
Article number	e0135991
Journal	PLoS ONE
Volume	10
Issue number	8
DOIs	https://doi.org/10.1371/journal.pone.0135991
Publication status	Published - 2015

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0135991

plos_Fritz

http://www.ncbi.nlm.nih.gov/pubmed/26287733?dopt=Abstract

1 Doctoral Thesis (compilation)

Axl RTK and microRNAs in urogenital cancers
Fritz, H., 2015, Translational Medicine. 218 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.",

abstract = "High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.",

author = "Helena Fritz and Anna Gustafsson and B{\"o}rje Ljungberg and Yvonne Ceder and H{\aa}kan Axelson and Bj{\"o}rn Dahlb{\"a}ck",

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journal = "PLoS ONE",

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T1 - The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

AU - Fritz, Helena

AU - Gustafsson, Anna

AU - Ljungberg, Börje

AU - Ceder, Yvonne

AU - Axelson, Håkan

AU - Dahlbäck, Björn

PY - 2015

Y1 - 2015

N2 - High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

AB - High expression of the receptor tyrosine kinase Axl is associated with poor prognosis in patients with Renal Cell Carcinoma (RCC), the most common malignancy of the kidney. The miR-34a has been shown to directly regulate Axl in cancer cells. The miR-34a is a mediator of p53-dependent tumor suppression, and low expression of miR-34a has been associated with worse prognosis in several cancers. Our aim was to elucidate whether miR-34a or the other members of the miR-34 family (miR-34b/c) regulate Axl in RCC.

U2 - 10.1371/journal.pone.0135991

DO - 10.1371/journal.pone.0135991

M3 - Article

C2 - 26287733

SN - 1932-6203

VL - 10

JO - PLoS ONE

JF - PLoS ONE

IS - 8

M1 - e0135991

ER -

The Axl-Regulating Tumor Suppressor miR-34a Is Increased in ccRCC but Does Not Correlate with Axl mRNA or Axl Protein Levels.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Axl RTK and microRNAs in urogenital cancers

Cite this