The Benefits and Harms of Botulinum Toxin-A in the Treatment of Chronic Pelvic Pain Syndromes: A Systematic Review by the European Association of Urology Chronic Pelvic Pain Panel

Brian A. Parsons, Sanchia Goonewardene, Saeed Dabestani, Luis Pacheco-Figueiredo, Yuhong Yuan, Valentin Zumstein, Angela M. Cottrell, Jan Borovicka, Paulo Dinis-Oliveira, Bary Berghmans, Sohier Elneil, John Hughes, Bert E.J. Messelink, Amanda C. de C Williams, Andrew P. Baranowski, Daniel S. Engeler

Research output: Contribution to journalReview articlepeer-review

5 Citations (SciVal)

Abstract

Chronic pelvic pain (CPP) is chronic or persistent pain perceived in structures related to the pelvis of men and women. Patients with CPP may have pain refractory to conventional management strategies. Botulinum toxin A (BTX-A) injection is a potential therapeutic option in patients with CPP. Beneficial effects of BTX-A on pain, quality of life, and functional symptoms were seen in patients with certain CPP subtypes, but the current evidence level is too weak to allow recommendations about the use of BTX-A for treating CPP. Therefore, larger-scale, multicentre, well-designed, and appropriately powered randomised controlled trials or prospective case-control studies with longer follow-up periods are needed.

Original languageEnglish
Pages (from-to)320-338
JournalEuropean Urology Focus
Volume8
Issue number1
Early online date2021 Jan 29
DOIs
Publication statusPublished - 2022

Subject classification (UKÄ)

  • Urology and Nephrology

Keywords

  • Bladder pain syndrome
  • Botulinum toxin A
  • Chronic anal fissure
  • Chronic pelvic pain syndrome
  • Gynaecological pain syndrome
  • Myofascial pelvic pain
  • Prostate pain syndrome

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