The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Niels Weinhold; David C. Johnson; Daniel Chubb; Bowang Chen; Asta Försti; Fay J. Hosking; Peter Broderick; Yussanne P. Ma; Sara E. Dobbins; Dirk Hose; Brian A. Walker; Faith E. Davies; Martin F. Kaiser; Ni L. Li; Walter A. Gregory; Graham H. Jackson; Mathias Witzens-Harig; Kai Neben; Per Hoffmann; Markus M. Noethen; Thomas W. Muehleisen; Lewin Eisele; Fiona M. Ross; Anna Jauch; Hartmut Goldschmidt; Richard S. Houlston; Gareth J. Morgan; Kari Hemminki

doi:10.1038/ng.2583

The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Niels Weinhold, David C. Johnson, Daniel Chubb, Bowang Chen, Asta Försti, Fay J. Hosking, Peter Broderick, Yussanne P. Ma, Sara E. Dobbins, Dirk Hose, Brian A. Walker, Faith E. Davies, Martin F. Kaiser, Ni L. Li, Walter A. Gregory, Graham H. Jackson, Mathias Witzens-Harig, Kai Neben, Per Hoffmann, Markus M. NoethenThomas W. Muehleisen, Lewin Eisele, Fiona M. Ross, Anna Jauch, Hartmut Goldschmidt, Richard S. Houlston, Gareth J. Morgan, Kari Hemminki

Research output: Contribution to journal › Article › peer-review

Abstract

A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

Original language	English
Pages (from-to)	522-525
Journal	Nature Genetics
Volume	45
Issue number	5
DOIs	https://doi.org/10.1038/ng.2583
Publication status	Published - 2013

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10.1038/ng.2583

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Weinhold, N., Johnson, D. C., Chubb, D., Chen, B., Försti, A., Hosking, F. J., Broderick, P., Ma, Y. P., Dobbins, S. E., Hose, D., Walker, B. A., Davies, F. E., Kaiser, M. F., Li, N. L., Gregory, W. A., Jackson, G. H., Witzens-Harig, M., Neben, K., Hoffmann, P., ... Hemminki, K. (2013). The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma. Nature Genetics, 45(5), 522-525. https://doi.org/10.1038/ng.2583

@article{e035bef84504472499cdfe5d35bec984,

title = "The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma",

abstract = "A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.",

author = "Niels Weinhold and Johnson, \{David C.\} and Daniel Chubb and Bowang Chen and Asta F{\"o}rsti and Hosking, \{Fay J.\} and Peter Broderick and Ma, \{Yussanne P.\} and Dobbins, \{Sara E.\} and Dirk Hose and Walker, \{Brian A.\} and Davies, \{Faith E.\} and Kaiser, \{Martin F.\} and Li, \{Ni L.\} and Gregory, \{Walter A.\} and Jackson, \{Graham H.\} and Mathias Witzens-Harig and Kai Neben and Per Hoffmann and Noethen, \{Markus M.\} and Muehleisen, \{Thomas W.\} and Lewin Eisele and Ross, \{Fiona M.\} and Anna Jauch and Hartmut Goldschmidt and Houlston, \{Richard S.\} and Morgan, \{Gareth J.\} and Kari Hemminki",

year = "2013",

doi = "10.1038/ng.2583",

language = "English",

volume = "45",

pages = "522--525",

journal = "Nature Genetics",

issn = "1546-1718",

publisher = "Nature Publishing Group",

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Weinhold, N, Johnson, DC, Chubb, D, Chen, B, Försti, A, Hosking, FJ, Broderick, P, Ma, YP, Dobbins, SE, Hose, D, Walker, BA, Davies, FE, Kaiser, MF, Li, NL, Gregory, WA, Jackson, GH, Witzens-Harig, M, Neben, K, Hoffmann, P, Noethen, MM, Muehleisen, TW, Eisele, L, Ross, FM, Jauch, A, Goldschmidt, H, Houlston, RS, Morgan, GJ & Hemminki, K 2013, 'The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma', Nature Genetics, vol. 45, no. 5, pp. 522-525. https://doi.org/10.1038/ng.2583

TY - JOUR

T1 - The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

AU - Weinhold, Niels

AU - Johnson, David C.

AU - Chubb, Daniel

AU - Chen, Bowang

AU - Försti, Asta

AU - Hosking, Fay J.

AU - Broderick, Peter

AU - Ma, Yussanne P.

AU - Dobbins, Sara E.

AU - Hose, Dirk

AU - Walker, Brian A.

AU - Davies, Faith E.

AU - Kaiser, Martin F.

AU - Li, Ni L.

AU - Gregory, Walter A.

AU - Jackson, Graham H.

AU - Witzens-Harig, Mathias

AU - Neben, Kai

AU - Hoffmann, Per

AU - Noethen, Markus M.

AU - Muehleisen, Thomas W.

AU - Eisele, Lewin

AU - Ross, Fiona M.

AU - Jauch, Anna

AU - Goldschmidt, Hartmut

AU - Houlston, Richard S.

AU - Morgan, Gareth J.

AU - Hemminki, Kari

PY - 2013

Y1 - 2013

N2 - A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

AB - A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhancer was strongly associated with the CCND1 c.870G>A polymorphism (P = 7.96 x 10(-11)). These results provide a model in which a constitutive genetic factor is associated with risk of a specific chromosomal translocation.

UR - https://www.scopus.com/pages/publications/84878596524

U2 - 10.1038/ng.2583

DO - 10.1038/ng.2583

M3 - Article

C2 - 23502783

SN - 1546-1718

VL - 45

SP - 522

EP - 525

JO - Nature Genetics

JF - Nature Genetics

IS - 5

ER -

The CCND1 c.870G > A polymorphism is a risk factor for t(11;14)(q13;q32) multiple myeloma

Abstract

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