The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Filip Ventorp; Cecilie Bay-Richter; Analise Sauro; Shorena Janelidze; Viktor Sjödahl Matsson; Jack Lipton; Ulrika Nordström; Åsa Westrin; Patrik Brundin; Lena Brundin

doi:10.1016/j.jad.2015.12.069

The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Filip Ventorp, Cecilie Bay-Richter, Analise Sauro, Shorena Janelidze, Viktor Sjödahl Matsson, Jack Lipton, Ulrika Nordström, Åsa Westrin, Patrik Brundin, Lena Brundin

Michigan State University

Research output: Contribution to journal › Article › peer-review

Abstract

The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.

Original language	English
Pages (from-to)	349-354
Journal	Journal of Affective Disorders
Volume	193
DOIs	https://doi.org/10.1016/j.jad.2015.12.069
Publication status	Published - 2016

Subject classification (UKÄ)

Psychiatry

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10.1016/j.jad.2015.12.069

http://www.ncbi.nlm.nih.gov/pubmed/26796235?dopt=Abstract

1 Doctoral Thesis (compilation)

Inflammatory Mechanisms of Depression and Suicidal Behavior
Ventorp, F., 2017, Lund: Lund University: Faculty of Medicine. 111 p.
Research output: Thesis › Doctoral Thesis (compilation)

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Individanpassad behandling av patienter med depression, med särskilt fokus på suicidrisk.
Westrin, Å., Asp, M., Lindqvist, D., Westling, S., Fernström, J., Hallberg, L., Ambrus, L. & Reis, M.
2012/01/02 → …
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Ventorp, F., Bay-Richter, C., Sauro, A., Janelidze, S., Matsson, V. S., Lipton, J., Nordström, U., Westrin, Å., Brundin, P., & Brundin, L. (2016). The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability. Journal of Affective Disorders, 193, 349-354. https://doi.org/10.1016/j.jad.2015.12.069

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title = "The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.",

abstract = "The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.",

author = "Filip Ventorp and Cecilie Bay-Richter and Analise Sauro and Shorena Janelidze and Matsson, {Viktor Sj{\"o}dahl} and Jack Lipton and Ulrika Nordstr{\"o}m and {\AA}sa Westrin and Patrik Brundin and Lena Brundin",

year = "2016",

doi = "10.1016/j.jad.2015.12.069",

language = "English",

volume = "193",

pages = "349--354",

journal = "Journal of Affective Disorders",

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Ventorp, F, Bay-Richter, C, Sauro, A, Janelidze, S, Matsson, VS, Lipton, J, Nordström, U, Westrin, Å, Brundin, P & Brundin, L 2016, 'The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.', Journal of Affective Disorders, vol. 193, pp. 349-354. https://doi.org/10.1016/j.jad.2015.12.069

TY - JOUR

T1 - The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

AU - Ventorp, Filip

AU - Bay-Richter, Cecilie

AU - Sauro, Analise

AU - Janelidze, Shorena

AU - Matsson, Viktor Sjödahl

AU - Lipton, Jack

AU - Nordström, Ulrika

AU - Westrin, Åsa

AU - Brundin, Patrik

AU - Brundin, Lena

PY - 2016

Y1 - 2016

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AB - The glycosaminoglycan hyaluronic acid (HA) is an important component of the extracellular matrix (ECM) in the brain. CD44 is a cell adhesion molecule that binds to HA in the ECM and is present on astrocytes, microglia and certain neurons. Cell adhesion molecules have been reported to be involved in anxiety and mood disorders. CD44 levels are decreased in the cerebrospinal fluid (CSF) of depressed individuals, and the CD44 gene has been identified in brain GWAS studies as a possible risk gene for suicidal behavior.

U2 - 10.1016/j.jad.2015.12.069

DO - 10.1016/j.jad.2015.12.069

M3 - Article

C2 - 26796235

SN - 0165-0327

VL - 193

SP - 349

EP - 354

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

ER -

The CD44 ligand hyaluronic acid is elevated in the cerebrospinal fluid of suicide attempters and is associated with increased blood-brain barrier permeability.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Research output

Inflammatory Mechanisms of Depression and Suicidal Behavior

Projects

Individanpassad behandling av patienter med depression, med särskilt fokus på suicidrisk.

Cite this