The clinicopathological and gene expression patterns associated with ulceration of primary melanoma

Rosalyn Jewell, Faye Elliott, Jonathan Laye, Jeremie Nsengimana, John Davies, Christy Walker, Caroline Conway, Angana Mitra, Mark Harland, Martin G. Cook, Andy Boon, Sarah Storr, Sabreena Safuan, Stewart G. Martin, Karin Jirström, Håkan Olsson, Christian Ingvar, Martin Lauss, Tim Bishop, Göran B JönssonJulia Newton-Bishop

Research output: Contribution to journalArticlepeer-review

25 Citations (SciVal)

Abstract

Ulceration of primary melanomas is associated with poor prognosis yet is reported to predict benefit from adjuvant interferon. To better understand the biological processes involved, clinicopathological factors associated with ulceration were determined in 1804 patients. From this cohort, 348 primary tumor blocks were sampled to generate gene expression data using a 502-gene cancer panel and 195 blocks were used for immunohistochemistry to detect macrophage infiltration and vessel density. Gene expression results were validated using a whole genome array in two independent sample sets. Ulceration of primary melanomas was associated with more proliferative tumors, tumor vessel invasion, and increased microvessel density. Infiltration of tumors with greater number of macrophages and gene expression pathways associated with wound healing and up-regulation of pro-inflammatory cytokines suggests that ulceration is associated with tumor-related inflammation. The relative benefit from interferon reported in patients with ulcerated tumors may reflect modification of signaling pathways involved in inflammation.
Original languageEnglish
Pages (from-to)94-104
JournalPigment Cell & Melanoma Research
Volume28
Issue number1
DOIs
Publication statusPublished - 2015

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Pathology, (Lund) (013030000), Oncology, MV (013035000), Surgery (Lund) (013009000)

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • melanoma
  • primary
  • ulceration
  • gene expression
  • clinicopathological
  • immunohistochemistry

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