Abstract
PURPOSE: To investigate the correlation of estrogen receptor (ER) gene polymorphism to dry eye syndrome in postmenopausal women. METHODS: Xba I and Pvu II polymorphism of ER gene were studied by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 65 patients with dry eye syndrome and 73 with controls in postmenopausal women. RESULTS: There was a significant difference of Pvu II polymorphism of ER gene between the patients of dry eye syndrome and controls in postmenopausal women (P < 0.05), but no significant difference was found in Xba I polymorphism of ER gene (P > 0.05). CONCLUSION: There is a significant correlation of Pvu II polymorphism of ER gene with dry eye syndrome in postmenopausal women. It is indicated that the difference in ER genotypes might influence the development of dry eye syndrome.
| Original language | Chinese |
|---|---|
| Pages (from-to) | 233-236 |
| Journal | Yanke xuebao (Visual Science) |
| Volume | 22 |
| Issue number | 4 |
| Publication status | Published - 2006 |
| Externally published | Yes |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)
Subject classification (UKÄ)
- Medicinal Chemistry