The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

Carl Sandén; Linnea Järvstråt; Andreas Lennartsson; Per Ludvik Brattaas; Björn Nilsson; Urban Gullberg

doi:10.1186/1476-4598-13-215

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

Carl Sandén, Linnea Järvstråt, Andreas Lennartsson, Per Ludvik Brattaas, Björn Nilsson, Urban Gullberg

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Abstract

The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.

Original language	English
Article number	215
Journal	Molecular Cancer
Volume	13
DOIs	https://doi.org/10.1186/1476-4598-13-215
Publication status	Published - 2014

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1186/1476-4598-13-215

BMC__Sanden_et_al

http://www.ncbi.nlm.nih.gov/pubmed/25216995?dopt=Abstract

1 Doctoral Thesis (compilation)

Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution
Järvstråt, L., 2017, Lund: Lund University: Faculty of Medicine. 42 p.
Research output: Thesis › Doctoral Thesis (compilation)

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title = "The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.",

abstract = "The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.",

author = "Carl Sand{\'e}n and Linnea J{\"a}rvstr{\aa}t and Andreas Lennartsson and Brattaas, {Per Ludvik} and Bj{\"o}rn Nilsson and Urban Gullberg",

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AU - Sandén, Carl

AU - Järvstråt, Linnea

AU - Lennartsson, Andreas

AU - Brattaas, Per Ludvik

AU - Nilsson, Björn

AU - Gullberg, Urban

PY - 2014

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N2 - The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.

AB - The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.

U2 - 10.1186/1476-4598-13-215

DO - 10.1186/1476-4598-13-215

M3 - Article

C2 - 25216995

SN - 1476-4598

VL - 13

JO - Molecular Cancer

JF - Molecular Cancer

M1 - 215

ER -

The DEK oncoprotein binds to highly and ubiquitously expressed genes with a dual role in their transcriptional regulation.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution

Cite this