The effect of natural biomolecules on yttrium oxide nanoparticles from a Daphnia magna survival rate perspective

Egle Kelpsiene, Tingru Chang, Aliaksandr Khort, Katja Bernfur, Inger Odnevall, Tommy Cedervall, Jing Hua

Research output: Contribution to journalArticlepeer-review

Abstract

The attention to rare earth oxide nanoparticles (NPs), including yttrium oxide (Y2O3), has increased in many fields due to their unique structural characteristics and functional properties. The aim of our study was to investigate the mechanisms by which bio-corona formation on Y2O3 NPs affects their environmental fate and toxicity. The Y2O3 NPs induced toxicity to freshwater filter feeder Daphnia magna at particle concentrations of 1 and 10 mg/L, regardless of particle size. Interactions between naturally excreted biomolecules (e.g. protein, lipids, and polysaccharides) derived from D. magna, and the Y2O3 NPs (30–45 nm) resulted in the formation of an eco-corona, which reduced their toxic effects toward D. magna at a particle concentration of 10 mg/L. No effects were observed at lower concentrations or for the other particle sizes investigated. Copper-zinc (Cu-Zn) superoxide dismutase, apolipophorins, and vitellogenin-1 proteins proved to be the most prominent proteins of the adsorbed corona, and possibly a reason for the reduced toxicity of the 30–45 nm Y2O3 NPs toward D. magna.

Original languageEnglish
Pages (from-to)385-399
Number of pages15
JournalNanotoxicology
Volume17
Issue number4
DOIs
Publication statusPublished - 2023

Subject classification (UKÄ)

  • Biochemistry and Molecular Biology
  • Physical Chemistry

Free keywords

  • Daphnia magna
  • metallic nanoparticles
  • natural biomolecules; biocorona
  • yttrium oxide nanoparticles

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