TY - JOUR
T1 - The effects of trifluoperazine on fast and slow axonal transport in the rabbit vagus nerve
AU - Ekström, Per
AU - Kanje, Martin
AU - McLean, W. Graham
PY - 1987
Y1 - 1987
N2 - The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of 3H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT‐system may be the main target of the drug.
AB - The effects of trifluoperazine (TFP) on fast and slow axonal transport (AXT) of labeled proteins were examined in the rabbit vagus nerve. Cuffs soaked in a 10 mM, but not 0.1 mM or 1 mM, concentration of TFP applied locally around the vagus nerve in vivo blocked both fast and slow AXT, as measured by the accumulation of 3H‐labeled proteins. In vitro, fast AXT was affected by 0.1 mM TFP. The TFP cuff treatment caused a reduction in the number of axonal microtubules (MT) whereas cuffs soaked in saline had no effect. The levels of ATP, ADP, and AMP were not significantly lowered by the TFP treatment. The results suggest that both fast and slow AXT are sensitive to TFP treatment, and that the axonal MT‐system may be the main target of the drug.
UR - http://www.scopus.com/inward/record.url?scp=0023218132&partnerID=8YFLogxK
U2 - 10.1002/neu.480180304
DO - 10.1002/neu.480180304
M3 - Article
C2 - 2439654
AN - SCOPUS:0023218132
SN - 0022-3034
VL - 18
SP - 283
EP - 293
JO - Journal of Neurobiology
JF - Journal of Neurobiology
IS - 3
ER -