The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

I Dahlman; I Sinha; H Gao; D Brodin; A Thorell; M Rydén; D P Andersson; J Henriksson; Alexander Perfilyev; Charlotte Ling; K Dahlman-Wright; P Arner

doi:10.1038/ijo.2015.31

The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

I Dahlman, I Sinha, H Gao, D Brodin, A Thorell, M Rydén, D P Andersson, J Henriksson, Alexander Perfilyev, Charlotte Ling, K Dahlman-Wright, P Arner

Research output: Contribution to journal › Article › peer-review

Abstract

Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity.

Original language	English
Pages (from-to)	910-919
Journal	International Journal of Obesity
Volume	39
Issue number	6
DOIs	https://doi.org/10.1038/ijo.2015.31
Publication status	Published - 2015

Subject classification (UKÄ)

Nutrition and Dietetics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/ijo.2015.31

http://www.ncbi.nlm.nih.gov/pubmed/25783037?dopt=Abstract

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Dahlman, I., Sinha, I., Gao, H., Brodin, D., Thorell, A., Rydén, M., Andersson, D. P., Henriksson, J., Perfilyev, A., Ling, C., Dahlman-Wright, K., & Arner, P. (2015). The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes. International Journal of Obesity, 39(6), 910-919. https://doi.org/10.1038/ijo.2015.31

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title = "The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.",

abstract = "Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity.",

author = "I Dahlman and I Sinha and H Gao and D Brodin and A Thorell and M Ryd{\'e}n and Andersson, {D P} and J Henriksson and Alexander Perfilyev and Charlotte Ling and K Dahlman-Wright and P Arner",

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doi = "10.1038/ijo.2015.31",

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Dahlman, I, Sinha, I, Gao, H, Brodin, D, Thorell, A, Rydén, M, Andersson, DP, Henriksson, J, Perfilyev, A , Ling, C, Dahlman-Wright, K & Arner, P 2015, 'The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.', International Journal of Obesity, vol. 39, no. 6, pp. 910-919. https://doi.org/10.1038/ijo.2015.31

TY - JOUR

T1 - The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

AU - Dahlman, I

AU - Sinha, I

AU - Gao, H

AU - Brodin, D

AU - Thorell, A

AU - Rydén, M

AU - Andersson, D P

AU - Henriksson, J

AU - Perfilyev, Alexander

AU - Ling, Charlotte

AU - Dahlman-Wright, K

AU - Arner, P

PY - 2015

Y1 - 2015

N2 - Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity.

AB - Obese subjects have increased number of enlarged fat cells which are reduced in size but not number in post-obesity. We performed DNA methylation profiling in fat cells with the aim of identifying differentially methylated DNA sites (DMS) linked to adipose hyperplasia (many small fat cells) in post-obesity.

U2 - 10.1038/ijo.2015.31

DO - 10.1038/ijo.2015.31

M3 - Article

C2 - 25783037

SN - 1476-5497

VL - 39

SP - 910

EP - 919

JO - International Journal of Obesity

JF - International Journal of Obesity

IS - 6

ER -

The fat cell epigenetic signature in post-obese women is characterized by global hypomethylation and differential DNA methylation of adipogenesis genes.

Abstract

Subject classification (UKÄ)

UN SDGs

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