The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

Jasper C A Broen; Marieke J H Coenen; Blanca Rueda; Torsten Witte; Leonid Padyukov; Lars Klareskog; Roger Hesselstrand; Dirk Wuttge; Carmen Simeon; Norberto Ortego-Centeno; Miguel González-Gay; Anna Pros; Nicholas Hunzelman; Gabriela Riemekasten; Alexander Kreuter; Madelon Vonk; Rafaella Scorza; Lorenzo Beretta; Paulo Airò; Piet L C M van Riel; Robert Kimberly; Javier Martin; Jeffrey Edberg; Timothy R D J Radstake

doi:10.3899/jrheum.100427

The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

Jasper C A Broen, Marieke J H Coenen, Blanca Rueda, Torsten Witte, Leonid Padyukov, Lars Klareskog, Roger Hesselstrand, Dirk Wuttge, Carmen Simeon, Norberto Ortego-Centeno, Miguel González-Gay, Anna Pros, Nicholas Hunzelman, Gabriela Riemekasten, Alexander Kreuter, Madelon Vonk, Rafaella Scorza, Lorenzo Beretta, Paulo Airò, Piet L C M van RielRobert Kimberly, Javier Martin, Jeffrey Edberg, Timothy R D J Radstake

Rheumatology

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

Original language	English
Pages (from-to)	446-449
Journal	Journal of Rheumatology
Volume	38
Issue number	3
DOIs	https://doi.org/10.3899/jrheum.100427
Publication status	Published - 2011

Subject classification (UKÄ)

Clinical Medicine

Access to Document

10.3899/jrheum.100427

http://www.ncbi.nlm.nih.gov/pubmed/21159834?dopt=Abstract

Cite this

Broen, J. C. A., Coenen, M. J. H., Rueda, B., Witte, T., Padyukov, L., Klareskog, L., Hesselstrand, R., Wuttge, D., Simeon, C., Ortego-Centeno, N., González-Gay, M., Pros, A., Hunzelman, N., Riemekasten, G., Kreuter, A., Vonk, M., Scorza, R., Beretta, L., Airò, P., ... Radstake, T. R. D. J. (2011). The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility. Journal of Rheumatology, 38(3), 446-449. https://doi.org/10.3899/jrheum.100427

@article{1ab2ba5c994a4e30b59c5bac837d9d58,

title = "The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.",

abstract = "OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.",

author = "Broen, {Jasper C A} and Coenen, {Marieke J H} and Blanca Rueda and Torsten Witte and Leonid Padyukov and Lars Klareskog and Roger Hesselstrand and Dirk Wuttge and Carmen Simeon and Norberto Ortego-Centeno and Miguel Gonz{\'a}lez-Gay and Anna Pros and Nicholas Hunzelman and Gabriela Riemekasten and Alexander Kreuter and Madelon Vonk and Rafaella Scorza and Lorenzo Beretta and Paulo Air{\`o} and {van Riel}, {Piet L C M} and Robert Kimberly and Javier Martin and Jeffrey Edberg and Radstake, {Timothy R D J}",

year = "2011",

doi = "10.3899/jrheum.100427",

language = "English",

volume = "38",

pages = "446--449",

journal = "Journal of Rheumatology",

issn = "0315-162X",

publisher = "Journal of Rheumatology",

number = "3",

}

Broen, JCA, Coenen, MJH, Rueda, B, Witte, T, Padyukov, L, Klareskog, L, Hesselstrand, R , Wuttge, D, Simeon, C, Ortego-Centeno, N, González-Gay, M, Pros, A, Hunzelman, N, Riemekasten, G, Kreuter, A, Vonk, M, Scorza, R, Beretta, L, Airò, P, van Riel, PLCM, Kimberly, R, Martin, J, Edberg, J & Radstake, TRDJ 2011, 'The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.', Journal of Rheumatology, vol. 38, no. 3, pp. 446-449. https://doi.org/10.3899/jrheum.100427

TY - JOUR

T1 - The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

AU - Broen, Jasper C A

AU - Coenen, Marieke J H

AU - Rueda, Blanca

AU - Witte, Torsten

AU - Padyukov, Leonid

AU - Klareskog, Lars

AU - Hesselstrand, Roger

AU - Wuttge, Dirk

AU - Simeon, Carmen

AU - Ortego-Centeno, Norberto

AU - González-Gay, Miguel

AU - Pros, Anna

AU - Hunzelman, Nicholas

AU - Riemekasten, Gabriela

AU - Kreuter, Alexander

AU - Vonk, Madelon

AU - Scorza, Rafaella

AU - Beretta, Lorenzo

AU - Airò, Paulo

AU - van Riel, Piet L C M

AU - Kimberly, Robert

AU - Martin, Javier

AU - Edberg, Jeffrey

AU - Radstake, Timothy R D J

PY - 2011

Y1 - 2011

N2 - OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

AB - OBJECTIVE: To investigate the role of the Fc(α)RI 844 A>G functional polymorphism in the genetic predisposition to rheumatoid arthritis (RA) and systemic sclerosis (SSc) susceptibility. METHODS: The study population was composed of 1401 patients with SSc, 642 patients with RA, and 1317 healthy controls. The Fc(α)RI (CD89) single-nucleotide polymorphism rs16986050 was genotyped by pyrosequencing. RESULTS: We observed no significant deviation of the genotype and allele frequencies in RA and SSc compared to controls. A metaanalysis and a recessive and dominant model yielded similar negative results. CONCLUSION: Our data show that the Fc(α)RI 844 A>G polymorphism is not associated with SSc or RA susceptibility.

U2 - 10.3899/jrheum.100427

DO - 10.3899/jrheum.100427

M3 - Article

C2 - 21159834

SN - 0315-162X

VL - 38

SP - 446

EP - 449

JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 3

ER -

The Functional Polymorphism 844 A>G in Fc{alpha}RI (CD89) Does Not Contribute to Systemic Sclerosis or Rheumatoid Arthritis Susceptibility.

Abstract

Subject classification (UKÄ)

Access to Document

Fingerprint

Cite this