TY - JOUR
T1 - The human melanoma proteome atlas-Defining the molecular pathology
AU - Betancourt, Lazaro Hiram
AU - Gil, Jeovanis
AU - Kim, Yonghyo
AU - Doma, Viktória
AU - Çakır, Uğur
AU - Sanchez, Aniel
AU - Murillo, Jimmy Rodriguez
AU - Kuras, Magdalena
AU - Parada, Indira Pla
AU - Sugihara, Yutaka
AU - Appelqvist, Roger
AU - Wieslander, Elisabet
AU - Welinder, Charlotte
AU - Velasquez, Erika
AU - de Almeida, Natália Pinto
AU - Woldmar, Nicole
AU - Marko-Varga, Matilda
AU - Pawłowski, Krzysztof
AU - Eriksson, Jonatan
AU - Szeitz, Beáta
AU - Baldetorp, Bo
AU - Ingvar, Christian
AU - Olsson, Håkan
AU - Lundgren, Lotta
AU - Lindberg, Henrik
AU - Oskolas, Henriett
AU - Lee, Boram
AU - Berge, Ethan
AU - Sjögren, Marie
AU - Eriksson, Carina
AU - Kim, Dasol
AU - Kwon, Ho Jeong
AU - Knudsen, Beatrice
AU - Rezeli, Melinda
AU - Hong, Runyu
AU - Horvatovich, Peter
AU - Miliotis, Tasso
AU - Nishimura, Toshihide
AU - Kato, Harubumi
AU - Steinfelder, Erik
AU - Oppermann, Madalina
AU - Miller, Ken
AU - Florindi, Francesco
AU - Zhou, Qimin
AU - Domont, Gilberto B
AU - Pizzatti, Luciana
AU - Nogueira, Fábio C.S.
AU - Horvath, Peter
AU - Szadai, Leticia
AU - Timar, Jozsef
AU - Karpati, Sarolta
AU - Szasz, A. Marcell
AU - Malm, Johan
AU - Fenyö, David
AU - Ekedahl, Henrik
AU - Németh, István Balázs
AU - Marko-Varga, György
N1 - © 2021 The Authors. Clinical and Translational Medicine published by John Wiley & Sons Australia, Ltd on behalf of Shanghai Institute of Clinical Bioinformatics.
PY - 2021
Y1 - 2021
N2 - The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.
AB - The MM500 study is an initiative to map the protein levels in malignant melanoma tumor samples, focused on in-depth histopathology coupled to proteome characterization. The protein levels and localization were determined for a broad spectrum of diverse, surgically isolated melanoma tumors originating from multiple body locations. More than 15,500 proteoforms were identified by mass spectrometry, from which chromosomal and subcellular localization was annotated within both primary and metastatic melanoma. The data generated by global proteomic experiments covered 72% of the proteins identified in the recently reported high stringency blueprint of the human proteome. This study contributes to the NIH Cancer Moonshot initiative combining detailed histopathological presentation with the molecular characterization for 505 melanoma tumor samples, localized in 26 organs from 232 patients.
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Cell Line, Tumor
KW - Chromatography, High Pressure Liquid
KW - Female
KW - Humans
KW - Male
KW - Melanoma/metabolism
KW - Middle Aged
KW - Proteome/analysis
KW - Proteomics/methods
KW - Skin Neoplasms/metabolism
KW - Tandem Mass Spectrometry
KW - Young Adult
U2 - 10.1002/ctm2.473
DO - 10.1002/ctm2.473
M3 - Article
C2 - 34323403
SN - 2001-1326
VL - 11
SP - 1
EP - 20
JO - Clinical and Translational Medicine
JF - Clinical and Translational Medicine
IS - 7
M1 - e473
ER -
