The impact of dyslipidaemia on incidence of coronary heart disease in Finns and Swedes with different categories of glucose tolerance

Lei Zhang, Qing Qiao, Tiina Laatikainen, Stefan Soderberg, Pekka Jousilahti, Altan Onat, Peter Nilsson, Jaakko Tuomilehto

Research output: Contribution to journalArticlepeer-review

10 Citations (SciVal)

Abstract

Background: The association of dyslipidaemia with incidence of coronary heart disease (CHD) has not been well studied in people with different glucose categories. Methods: Data from six population-based prospective studies in Finland and Sweden, with 4818 men and 4269 women aged 25-89 years who were free of CHD and without a prior history of diabetes at baseline, were jointly analysed. Multivariate-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for CHD incidence were estimated. Results: 457 participants developed CHD during follow-up of 10 years. The multivariate adjusted HRs (95% CIs) for CHD incidence were 1.39 (1.08-1.80), 0.57 (0.39-0.84), 1.21 (1.07-1.37), 1.56 (1.21-2.01) and 1.74 (1.34-2.26), respectively, corresponding to a one unit increase in Z-scores of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), non-HDL-C and TC to HDL ratio, in people with newly diagnosed diabetes. The prediction was also significant in non-diabetic population except for TG in individuals with normoglycaemia and TG and HDL-C in those with isolated IFG. Conclusion: Adverse lipid profiles were related to increased CHD incidence in normoglycaemic, fasting hyperglycaemic and diabetic individuals, but not in people with IGT. The findings may imply considering different management strategies in people with fasting or post-load hyperglycaemia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)406-412
JournalDiabetes Research and Clinical Practice
Volume91
Issue number3
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Endocrinology and Diabetes

Keywords

  • Coronary heart disease
  • Lipid
  • Diabetes
  • Impaired glucose tolerance
  • Impaired fasting glucose

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