The impact of inflammatory lipid mediators on colon cancer-initiating cells.

Kishan Bellamkonda, Wondossen Sime, Anita Sjölander

Research output: Contribution to journalArticlepeer-review


The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc.
Original languageEnglish
Pages (from-to)1315-1327
JournalMolecular Carcinogenesis
Issue number11
Publication statusPublished - 2015

Subject classification (UKÄ)

  • Cancer and Oncology


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