The impact of inflammatory lipid mediators on colon cancer-initiating cells.

Kishan Bellamkonda; Wondossen Sime; Anita Sjölander

doi:10.1002/mc.22207

The impact of inflammatory lipid mediators on colon cancer-initiating cells.

Kishan Bellamkonda, Wondossen Sime, Anita Sjölander

Cell Pathology, Malmö

Research output: Contribution to journal › Article › peer-review

Abstract

The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc.

Original language	English
Pages (from-to)	1315-1327
Journal	Molecular Carcinogenesis
Volume	54
Issue number	11
DOIs	https://doi.org/10.1002/mc.22207
Publication status	Published - 2015

Subject classification (UKÄ)

Cancer and Oncology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mc.22207

http://www.ncbi.nlm.nih.gov/pubmed/25154976?dopt=Abstract

1 Doctoral Thesis (compilation)

The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)
Bellamkonda, K., 2015, Department of Laboratory Medicine, Lund University. 60 p.
Research output: Thesis › Doctoral Thesis (compilation)

File

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title = "The impact of inflammatory lipid mediators on colon cancer-initiating cells.",

abstract = "The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. {\textcopyright} 2014 Wiley Periodicals, Inc.",

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language = "English",

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pages = "1315--1327",

journal = "Molecular Carcinogenesis",

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T1 - The impact of inflammatory lipid mediators on colon cancer-initiating cells.

AU - Bellamkonda, Kishan

AU - Sime, Wondossen

AU - Sjölander, Anita

PY - 2015

Y1 - 2015

N2 - The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc.

AB - The role of inflammatory lipid-mediators in tumor progression is well recognized in colorectal cancer; however, if this includes promotion of cancer-initiating cells remains unclear. We show that the inflammatory lipid-mediators leukotriene D4 and prostaglandin E2 increased the Aldehyde dehydrogenase (ALDH(+) ) population, the colony formation capacity, and tumor growth in a xenograft model of colon cancer. The ALDH(+) cells showed significant resistance to irradiation and 5-fluorouracil treatment that could be further augmented by these lipid-mediators, occurring in parallel with increased target gene expression. Our data emphasize a role for tumor microenvironment derived inflammatory lipid-mediators to favor cancer stem cells-like characteristics and thus promote tumor progression. © 2014 Wiley Periodicals, Inc.

U2 - 10.1002/mc.22207

DO - 10.1002/mc.22207

M3 - Article

C2 - 25154976

SN - 1098-2744

VL - 54

SP - 1315

EP - 1327

JO - Molecular Carcinogenesis

JF - Molecular Carcinogenesis

IS - 11

ER -

The impact of inflammatory lipid mediators on colon cancer-initiating cells.

Abstract

Subject classification (UKÄ)

UN SDGs

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Research output

The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)

Cite this