The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

Joseph A Jakubowski; Dominick J Angiolillo; Chunmei Zhou; David S Small; Brian A Moser; Jurrien M Ten Berg; Patricia B Brown; Stefan James; Kenneth J Winters; David Erlinge

doi:10.1016/j.thromres.2014.05.019

The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

Joseph A Jakubowski, Dominick J Angiolillo, Chunmei Zhou, David S Small, Brian A Moser, Jurrien M Ten Berg, Patricia B Brown, Stefan James, Kenneth J Winters, David Erlinge

Cardiology

Research output: Contribution to journal › Article › peer-review

Abstract

Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.

Original language	English
Pages (from-to)	552-557
Journal	Thrombosis Research
Volume	134
Issue number	3
DOIs	https://doi.org/10.1016/j.thromres.2014.05.019
Publication status	Published - 2014

Subject classification (UKÄ)

Cardiac and Cardiovascular Systems

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10.1016/j.thromres.2014.05.019

http://www.ncbi.nlm.nih.gov/pubmed/25022828?dopt=Abstract

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Jakubowski, J. A., Angiolillo, D. J., Zhou, C., Small, D. S., Moser, B. A., Ten Berg, J. M., Brown, P. B., James, S., Winters, K. J., & Erlinge, D. (2014). The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study. Thrombosis Research, 134(3), 552-557. https://doi.org/10.1016/j.thromres.2014.05.019

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title = "The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.",

abstract = "Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.",

author = "Jakubowski, {Joseph A} and Angiolillo, {Dominick J} and Chunmei Zhou and Small, {David S} and Moser, {Brian A} and {Ten Berg}, {Jurrien M} and Brown, {Patricia B} and Stefan James and Winters, {Kenneth J} and David Erlinge",

year = "2014",

doi = "10.1016/j.thromres.2014.05.019",

language = "English",

volume = "134",

pages = "552--557",

journal = "Thrombosis Research",

issn = "1879-2472",

publisher = "Elsevier",

number = "3",

}

Jakubowski, JA, Angiolillo, DJ, Zhou, C, Small, DS, Moser, BA, Ten Berg, JM, Brown, PB, James, S, Winters, KJ & Erlinge, D 2014, 'The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.', Thrombosis Research, vol. 134, no. 3, pp. 552-557. https://doi.org/10.1016/j.thromres.2014.05.019

TY - JOUR

T1 - The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

AU - Jakubowski, Joseph A

AU - Angiolillo, Dominick J

AU - Zhou, Chunmei

AU - Small, David S

AU - Moser, Brian A

AU - Ten Berg, Jurrien M

AU - Brown, Patricia B

AU - James, Stefan

AU - Winters, Kenneth J

AU - Erlinge, David

PY - 2014

Y1 - 2014

N2 - Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.

AB - Patients treated with clopidogrel who have higher body size exhibit greater platelet reactivity than patients with lower body size. In a retrospective analysis of the FEATHER trial, we examined the relationship between platelet response to thienopyridines clopidogrel 75mg (Clop-75), prasugrel 5mg (Pras-5), and prasugrel 10mg (Pras-10) using 3 body size indices: body weight (BW), body mass index (BMI), and body surface area (BSA). Relationships were assessed as continuous variables and as 4 incremental body size groups.

U2 - 10.1016/j.thromres.2014.05.019

DO - 10.1016/j.thromres.2014.05.019

M3 - Article

C2 - 25022828

SN - 1879-2472

VL - 134

SP - 552

EP - 557

JO - Thrombosis Research

JF - Thrombosis Research

IS - 3

ER -

The influence of body size on the pharmacodynamic and pharmacokinetic response to clopidogrel and prasugrel: A retrospective analysis of the FEATHER study.

Abstract

Subject classification (UKÄ)

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