The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin

T. Pinheiro; Jan Pallon; L. C. Alves; A. Verissimo; P. Filipe; J. N. Silva; R. Silva

doi:10.1016/j.nimb.2007.02.014

The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin

T. Pinheiro, Jan Pallon, L. C. Alves, A. Verissimo, P. Filipe, J. N. Silva, R. Silva

Research output: Contribution to journal › Article › peer-review

Abstract

The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved.

Original language	English
Pages (from-to)	119-123
Journal	Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms
Volume	260
Issue number	1
DOIs	https://doi.org/10.1016/j.nimb.2007.02.014
Publication status	Published - 2007

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)

Subject classification (UKÄ)

Subatomic Physics

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1016/j.nimb.2007.02.014

Cite this

Pinheiro, T., Pallon, J., Alves, L. C., Verissimo, A., Filipe, P., Silva, J. N., & Silva, R. (2007). The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin. Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, 260(1), 119-123. https://doi.org/10.1016/j.nimb.2007.02.014

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title = "The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin",

abstract = "The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved.",

author = "T. Pinheiro and Jan Pallon and Alves, {L. C.} and A. Verissimo and P. Filipe and Silva, {J. N.} and R. Silva",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)",

year = "2007",

doi = "10.1016/j.nimb.2007.02.014",

language = "English",

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Pinheiro, T, Pallon, J, Alves, LC, Verissimo, A, Filipe, P, Silva, JN & Silva, R 2007, 'The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin', Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, vol. 260, no. 1, pp. 119-123. https://doi.org/10.1016/j.nimb.2007.02.014

The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin. / Pinheiro, T.; Pallon, Jan; Alves, L. C. et al.
In: Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms, Vol. 260, No. 1, 2007, p. 119-123.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin

AU - Pinheiro, T.

AU - Pallon, Jan

AU - Alves, L. C.

AU - Verissimo, A.

AU - Filipe, P.

AU - Silva, J. N.

AU - Silva, R.

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Nuclear Physics (Faculty of Technology) (011013007)

PY - 2007

Y1 - 2007

N2 - The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved.

AB - The permeability of skin to nanoparticles of titanium dioxide (TiO2) used in sunscreens as a reflector of the UV wavelengths of sunlight, was examined using nuclear microscopy techniques. Special attention was given to the permeation characteristics of these nanoparticles across the outer layers of skin, the stratum corneum, in healthy and psoriatic skin condition. Aspects that may influence the interpretation of results such as sample preparation difficulties and skin condition were focused. Sample preparation can damage the integrity of the corneocyte layers inducing unwanted artefacts that may bias the evaluation of results. Irradiation conditions may also introduce distortions in the labile structures of human skin. Skin condition, such as loss of corneocyte cohesion occurring in psoriasis also influence the permeation profile of the nanoparticles. Weighing and accounting for these features in the examination of skin by nuclear microscopy is crucial to accurately assess the TiO2 nanoparticles permeation depth. (c) 2007 Elsevier B.V. All rights reserved.

U2 - 10.1016/j.nimb.2007.02.014

DO - 10.1016/j.nimb.2007.02.014

M3 - Article

SN - 0168-583X

VL - 260

SP - 119

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JO - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

JF - Nuclear Instruments & Methods in Physics Research. Section B: Beam Interactions with Materials and Atoms

IS - 1

ER -

The influence of corneocyte structure on the interpretation of permeation profiles of nanoparticles across skin

Abstract

Bibliographical note

Subject classification (UKÄ)

UN SDGs

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Cite this