The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Esther Roura; Noémie Travier; Tim Waterboer; Silvia de Sanjosé; F Xavier Bosch; Michael Pawlita; Valeria Pala; Elisabete Weiderpass; Núria Margall; Joakim Dillner; Inger T Gram; Anne Tjønneland; Christian Munk; Domenico Palli; Kay-Tee Khaw; Kim Overvad; Françoise Clavel-Chapelon; Sylvie Mesrine; Agnès Fournier; Renée T Fortner; Jennifer Ose; Annika Steffen; Antonia Trichopoulou; Pagona Lagiou; Philippos Orfanos; Giovanna Masala; Rosario Tumino; Carlotta Sacerdote; Silvia Polidoro; Amalia Mattiello; Eiliv Lund; Petra H Peeters; H B As Bueno-de-Mesquita; J Ramón Quirós; María-José Sánchez; Carmen Navarro; Aurelio Barricarte; Nerea Larrañaga; Johanna Ekström; David Lindquist; Annika Idahl; Ruth C Travis; Melissa A Merritt; Marc J Gunter; Sabina Rinaldi; Massimo Tommasino; Silvia Franceschi; Elio Riboli; Xavier Castellsagué

doi:10.1371/journal.pone.0147029

The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Esther Roura, Noémie Travier, Tim Waterboer, Silvia de Sanjosé, F Xavier Bosch, Michael Pawlita, Valeria Pala, Elisabete Weiderpass, Núria Margall, Joakim Dillner, Inger T Gram, Anne Tjønneland, Christian Munk, Domenico Palli, Kay-Tee Khaw, Kim Overvad, Françoise Clavel-Chapelon, Sylvie Mesrine, Agnès Fournier, Renée T FortnerJennifer Ose, Annika Steffen, Antonia Trichopoulou, Pagona Lagiou, Philippos Orfanos, Giovanna Masala, Rosario Tumino, Carlotta Sacerdote, Silvia Polidoro, Amalia Mattiello, Eiliv Lund, Petra H Peeters, H B As Bueno-de-Mesquita, J Ramón Quirós, María-José Sánchez, Carmen Navarro, Aurelio Barricarte, Nerea Larrañaga, Johanna Ekström, David Lindquist, Annika Idahl, Ruth C Travis, Melissa A Merritt, Marc J Gunter, Sabina Rinaldi, Massimo Tommasino, Silvia Franceschi, Elio Riboli, Xavier Castellsagué

Internal Medicine - Epidemiology

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Abstract

In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC).

Original language	English
Article number	e0147029
Journal	PLoS ONE
Volume	11
Issue number	1
DOIs	https://doi.org/10.1371/journal.pone.0147029
Publication status	Published - 2016

Subject classification (UKÄ)

Cancer and Oncology

Free keywords

Human papillomavirus infection
Contraceptives
Estrogens
Hormonal therapy
Cohort studies
Cervical cancer
Case-control studies
Serology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1371/journal.pone.0147029

PLOS_Roura_et_al

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Roura, E., Travier, N., Waterboer, T., de Sanjosé, S., Bosch, F. X., Pawlita, M., Pala, V., Weiderpass, E., Margall, N., Dillner, J., Gram, I. T., Tjønneland, A., Munk, C., Palli, D., Khaw, K.-T., Overvad, K., Clavel-Chapelon, F., Mesrine, S., Fournier, A., ... Castellsagué, X. (2016). The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort. PLoS ONE, 11(1), Article e0147029. https://doi.org/10.1371/journal.pone.0147029

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title = "The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort",

abstract = "In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC).",

keywords = "Human papillomavirus infection, Contraceptives, Estrogens, Hormonal therapy, Cohort studies, Cervical cancer, Case-control studies, Serology",

author = "Esther Roura and No{\'e}mie Travier and Tim Waterboer and {de Sanjos{\'e}}, Silvia and Bosch, {F Xavier} and Michael Pawlita and Valeria Pala and Elisabete Weiderpass and N{\'u}ria Margall and Joakim Dillner and Gram, {Inger T} and Anne Tj{\o}nneland and Christian Munk and Domenico Palli and Kay-Tee Khaw and Kim Overvad and Fran{\c c}oise Clavel-Chapelon and Sylvie Mesrine and Agn{\`e}s Fournier and Fortner, {Ren{\'e}e T} and Jennifer Ose and Annika Steffen and Antonia Trichopoulou and Pagona Lagiou and Philippos Orfanos and Giovanna Masala and Rosario Tumino and Carlotta Sacerdote and Silvia Polidoro and Amalia Mattiello and Eiliv Lund and Peeters, {Petra H} and Bueno-de-Mesquita, {H B As} and Quir{\'o}s, {J Ram{\'o}n} and Mar{\'i}a-Jos{\'e} S{\'a}nchez and Carmen Navarro and Aurelio Barricarte and Nerea Larra{\~n}aga and Johanna Ekstr{\"o}m and David Lindquist and Annika Idahl and Travis, {Ruth C} and Merritt, {Melissa A} and Gunter, {Marc J} and Sabina Rinaldi and Massimo Tommasino and Silvia Franceschi and Elio Riboli and Xavier Castellsagu{\'e}",

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language = "English",

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Roura, E, Travier, N, Waterboer, T, de Sanjosé, S, Bosch, FX, Pawlita, M, Pala, V, Weiderpass, E, Margall, N, Dillner, J, Gram, IT, Tjønneland, A, Munk, C, Palli, D, Khaw, K-T, Overvad, K, Clavel-Chapelon, F, Mesrine, S, Fournier, A, Fortner, RT, Ose, J, Steffen, A, Trichopoulou, A, Lagiou, P, Orfanos, P, Masala, G, Tumino, R, Sacerdote, C, Polidoro, S, Mattiello, A, Lund, E, Peeters, PH, Bueno-de-Mesquita, HBA, Quirós, JR, Sánchez, M-J, Navarro, C, Barricarte, A, Larrañaga, N, Ekström, J, Lindquist, D, Idahl, A, Travis, RC, Merritt, MA, Gunter, MJ, Rinaldi, S, Tommasino, M, Franceschi, S, Riboli, E & Castellsagué, X 2016, 'The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort', PLoS ONE, vol. 11, no. 1, e0147029. https://doi.org/10.1371/journal.pone.0147029

TY - JOUR

T1 - The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

AU - Roura, Esther

AU - Travier, Noémie

AU - Waterboer, Tim

AU - de Sanjosé, Silvia

AU - Bosch, F Xavier

AU - Pawlita, Michael

AU - Pala, Valeria

AU - Weiderpass, Elisabete

AU - Margall, Núria

AU - Dillner, Joakim

AU - Gram, Inger T

AU - Tjønneland, Anne

AU - Munk, Christian

AU - Palli, Domenico

AU - Khaw, Kay-Tee

AU - Overvad, Kim

AU - Clavel-Chapelon, Françoise

AU - Mesrine, Sylvie

AU - Fournier, Agnès

AU - Fortner, Renée T

AU - Ose, Jennifer

AU - Steffen, Annika

AU - Trichopoulou, Antonia

AU - Lagiou, Pagona

AU - Orfanos, Philippos

AU - Masala, Giovanna

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Polidoro, Silvia

AU - Mattiello, Amalia

AU - Lund, Eiliv

AU - Peeters, Petra H

AU - Bueno-de-Mesquita, H B As

AU - Quirós, J Ramón

AU - Sánchez, María-José

AU - Navarro, Carmen

AU - Barricarte, Aurelio

AU - Larrañaga, Nerea

AU - Ekström, Johanna

AU - Lindquist, David

AU - Idahl, Annika

AU - Travis, Ruth C

AU - Merritt, Melissa A

AU - Gunter, Marc J

AU - Rinaldi, Sabina

AU - Tommasino, Massimo

AU - Franceschi, Silvia

AU - Riboli, Elio

AU - Castellsagué, Xavier

PY - 2016

Y1 - 2016

N2 - In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC).

AB - In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer (ICC).

KW - Human papillomavirus infection

KW - Contraceptives

KW - Estrogens

KW - Hormonal therapy

KW - Cohort studies

KW - Cervical cancer

KW - Case-control studies

KW - Serology

U2 - 10.1371/journal.pone.0147029

DO - 10.1371/journal.pone.0147029

M3 - Article

C2 - 26808155

SN - 1932-6203

VL - 11

JO - PLoS ONE

JF - PLoS ONE

IS - 1

M1 - e0147029

ER -

The Influence of Hormonal Factors on the Risk of Developing Cervical Cancer and Pre-Cancer: Results from the EPIC Cohort

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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