The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Anders Örbom; Sophie Eriksson; Erika Elgström; Tomas G Ohlsson; Rune Nilsson; Jan Tennvall; Sven-Erik Strand

doi:10.2967/jnumed.112.117028

The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Anders Örbom, Sophie Eriksson, Erika Elgström, Tomas G Ohlsson, Rune Nilsson, Jan Tennvall, Sven-Erik Strand

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Abstract

The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

Original language	English
Pages (from-to)	1404-1410
Journal	Journal of Nuclear Medicine
Volume	54
Issue number	8
DOIs	https://doi.org/10.2967/jnumed.112.117028
Publication status	Published - 2013

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SDG 3 Good Health and Well-being

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Radiology and Medical Imaging

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10.2967/jnumed.112.117028

Society_of_Nuclear_Medicine_Arbom_et_al

http://www.ncbi.nlm.nih.gov/pubmed/23804328?dopt=Abstract

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title = "The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.",

abstract = "The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.",

author = "Anders {\"O}rbom and Sophie Eriksson and Erika Elgstr{\"o}m and Ohlsson, \{Tomas G\} and Rune Nilsson and Jan Tennvall and Sven-Erik Strand",

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language = "English",

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AU - Örbom, Anders

AU - Eriksson, Sophie

AU - Elgström, Erika

AU - Ohlsson, Tomas G

AU - Nilsson, Rune

AU - Tennvall, Jan

AU - Strand, Sven-Erik

PY - 2013

Y1 - 2013

N2 - The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

AB - The therapeutic effect of radioimmunotherapy depends on the distribution of the absorbed dose in relation to viable cancer cells within the tumor, which in turn is a function of the activity distribution. The aim of this study was to investigate the distribution of (177)Lu-DOTA-BR96 monoclonal antibodies targeting the Lewis Y antigen over 7 d using a syngeneic rat model of colon carcinoma.

UR - https://www.scopus.com/pages/publications/84876839931

U2 - 10.2967/jnumed.112.117028

DO - 10.2967/jnumed.112.117028

M3 - Article

C2 - 23804328

SN - 0161-5505

VL - 54

SP - 1404

EP - 1410

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

IS - 8

ER -

The Intratumoral Distribution of Radiolabeled 177Lu-BR96 Monoclonal Antibodies Changes in Relation to Tumor Histology over Time in a Syngeneic Rat Colon Carcinoma Model.

Abstract

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