Abstract
The role of the DEK protein, involved in the leukemia-associated fusion protein DEK-CAN, is not yet known. In this study, we show a higher expression of DEK mRNA in immature cells than in mature cells. Furthermore, a correlation between DEK expression and cell proliferation was demonstrated, suggesting that DEK plays a role in the proliferation of hematopoietic cells and raising the question of whether the DEK-CAN fusion protein might perturb regulation of proliferation in leukemic cells.
Original language | English |
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Pages (from-to) | 268-269 |
Journal | Haematologica |
Volume | 91 |
Issue number | 2 |
Publication status | Published - 2006 |
Subject classification (UKÄ)
- Hematology
Free keywords
- leukemia
- DEK
- proliferation