Abstract
Many bacterial effector proteins that are delivered to host cells during infection are enzymes targeting host cell signalling. Recently, Legionella pneumophila effector Lpg1137 was experimentally characterised as a serine protease that cleaves human syntaxin 17. We present strong bioinformatic evidence that Lpg1137 is a homologue of mitochondrial carrier proteins and is not related to known serine proteases. We also discuss how this finding can be reconciled with the apparently contradictory experimental results.
| Original language | English |
|---|---|
| Article number | e3849 |
| Journal | PeerJ |
| Volume | 2017 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - 2017 |
Subject classification (UKÄ)
- Cell and Molecular Biology
- Other Clinical Medicine
Free keywords
- Bacterial effectors
- Mitochondrial carriers
- Proteases
- Structure prediction