@inbook{7bd8c4c12b3e4e9982aee4eccde3302c,
title = "The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.",
abstract = "The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.",
author = "Christian Kamp-Nielsen and John {\"O}hd and Katarina Wikstr{\"o}m and Ramin Massoumi and Sailaja Paruchuri and Maria Juhas and Anita Sj{\"o}lander",
year = "2003",
doi = "10.1007/978-1-4419-9194-2_43",
language = "English",
isbn = "978-0-306-47763-8",
volume = "525",
series = "Advances in Experimental Medicine and Biology",
publisher = "Springer",
pages = "201--204",
booktitle = "Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research",
address = "Germany",
}
