The leukotriene receptor CysLT1 and 5-lipoxygenase are upregulated in colon cancer.

Christian Kamp-Nielsen, John Öhd, Katarina Wikström, Ramin Massoumi, Sailaja Paruchuri, Maria Juhas, Anita Sjölander

Research output: Chapter in Book/Report/Conference proceedingBook chapterResearchpeer-review


The metabolites of arachidonic acid are well connected to pathological situations such as inflammation, cancer and asthmA. Sheng et al. [7] found that COX-2 is upregulated in colon cancer tissue and tumor cell lines indicating that COX-2 is involved in colon cancer. This is supported by studies showing that patients treated with nonsteroidal anti-inflammatory drugs, inhibitors of COX-2, exhibit a lower frequency of colon cancer [8]. When the non-transformed intestinal epithelial cell line, Int 407 was stimulated with LTD4 or LTB4 we observed an accumulation of COX-2 in membrane fractions as well as an increased production of prostaglandin E2 [5]. Treatment of these cells with the COX-2 inhibitor NS-398 caused apoptosis and this effect could be prevented by LTD4 [5] or LTB4 [4]. Similar results were obtained when cell viability with LTD4 or LTB4 in the presence or absence of NS-398 was assayed [4,5]. The results demonstrate that these leukotrienes can suppress the NS-398 induced apoptosis in intestinal cells.
Original languageEnglish
Title of host publicationAdvances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research
ISBN (Print)978-0-306-47763-8
Publication statusPublished - 2003

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Electronic)0065-2598

Subject classification (UKÄ)

  • Cancer and Oncology


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