The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Evald Rosengren, Pierre Åman, Sofia Thelin, Christer Hansson, Stefan Ahlfors, Peter Björk, Lars Jacobsson, Hans Rorsman

Research output: Contribution to journalArticlepeer-review


A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.
Original languageEnglish
Pages (from-to)85-88
JournalFEBS Letters
Issue number1
Publication statusPublished - 1997

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)

Subject classification (UKÄ)

  • Biological Sciences

Free keywords

  • Macrophage migration inhibitory factor
  • Phenylpyruvate tautomerase
  • Dopachrome tautomerase
  • Cytokine


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