The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Evald Rosengren; Pierre Åman; Sofia Thelin; Christer Hansson; Stefan Ahlfors; Peter Björk; Lars Jacobsson; Hans Rorsman

doi:10.1016/S0014-5793(97)01261-1

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Evald Rosengren, Pierre Åman, Sofia Thelin, Christer Hansson, Stefan Ahlfors, Peter Björk, Lars Jacobsson, Hans Rorsman

Research output: Contribution to journal › Article › peer-review

Abstract

A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

Original language	English
Pages (from-to)	85-88
Journal	FEBS Letters
Volume	417
Issue number	1
DOIs	https://doi.org/10.1016/S0014-5793(97)01261-1
Publication status	Published - 1997

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)

Subject classification (UKÄ)

Biological Sciences

Free keywords

Macrophage migration inhibitory factor
Phenylpyruvate tautomerase
Dopachrome tautomerase
Cytokine

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10.1016/S0014-5793(97)01261-1

Cite this

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title = "The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase",

abstract = "A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.",

keywords = "Macrophage migration inhibitory factor, Phenylpyruvate tautomerase, Dopachrome tautomerase, Cytokine",

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note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)",

year = "1997",

doi = "10.1016/S0014-5793(97)01261-1",

language = "English",

volume = "417",

pages = "85--88",

journal = "FEBS Letters",

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publisher = "Wiley-Blackwell",

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TY - JOUR

T1 - The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

AU - Rosengren, Evald

AU - Åman, Pierre

AU - Thelin, Sofia

AU - Hansson, Christer

AU - Ahlfors, Stefan

AU - Björk, Peter

AU - Jacobsson, Lars

AU - Rorsman, Hans

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)

PY - 1997

Y1 - 1997

N2 - A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

AB - A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.

KW - Macrophage migration inhibitory factor

KW - Phenylpyruvate tautomerase

KW - Dopachrome tautomerase

KW - Cytokine

U2 - 10.1016/S0014-5793(97)01261-1

DO - 10.1016/S0014-5793(97)01261-1

M3 - Article

SN - 1873-3468

VL - 417

SP - 85

EP - 88

JO - FEBS Letters

JF - FEBS Letters

IS - 1

ER -

The macrophage migration inhibitory factor MIF is a phenylpyruvate tautomerase

Abstract

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Subject classification (UKÄ)

Free keywords

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