Abstract
A macrophage migration inhibitory factor (MIF), originally described as a product of activated lymphocytes, has been defined as a 12 kDa protein, expressed in a wide variety of tissues. Here MIF is identified as a phenylpyruvate tautomerase (EC 5.3.2.1) having p-hydroxyphenylpyruvate and phenylpyruvate as its natural substrates. The definition of MIF as an enzyme may yield insight into the mechanism of action of this proinflammatory and immunomodulating cytokine.
Original language | English |
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Pages (from-to) | 85-88 |
Journal | FEBS Letters |
Volume | 417 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1997 |
Bibliographical note
The information about affiliations in this record was updated in December 2015.The record was previously connected to the following departments: Emergency medicine/Medicine/Surgery (013240200), Department of Dermatology and Venereology (Lund) (013006000), Department of Experimental Medical Science (013210000)
Subject classification (UKÄ)
- Biological Sciences
Free keywords
- Macrophage migration inhibitory factor
- Phenylpyruvate tautomerase
- Dopachrome tautomerase
- Cytokine