The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Rosellina Margherita Mancina; Paola Dongiovanni; Salvatore Petta; Piero Pingitore; Marica Meroni; Raffaela Rametta; Jan Borén; Tiziana Montalcini; Arturo Pujia; Olov Wiklund; George Hindy; Rocco Spagnuolo; Benedetta Maria Motta; Rosaria Maria Pipitone; Antonio Craxì; Silvia Fargion; Valerio Nobili; Pirjo Käkelä; Vesa Kärjä; Ville Männistö; Jussi Pihlajamäki; Dermot F Reilly; Jose Castro-Perez; Julia Kozlitina; Luca Valenti; Stefano Romeo

doi:10.1053/j.gastro.2016.01.032

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Rosellina Margherita Mancina, Paola Dongiovanni, Salvatore Petta, Piero Pingitore, Marica Meroni, Raffaela Rametta, Jan Borén, Tiziana Montalcini, Arturo Pujia, Olov Wiklund, George Hindy, Rocco Spagnuolo, Benedetta Maria Motta, Rosaria Maria Pipitone, Antonio Craxì, Silvia Fargion, Valerio Nobili, Pirjo Käkelä, Vesa Kärjä, Ville MännistöJussi Pihlajamäki, Dermot F Reilly, Jose Castro-Perez, Julia Kozlitina, Luca Valenti, Stefano Romeo

Research output: Contribution to journal › Article › peer-review

Abstract

Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.

Original language	English
Pages (from-to)	1219-1230e6
Journal	Gastroenterology
Volume	150
Issue number	5
Early online date	2016 Feb 2
DOIs	https://doi.org/10.1053/j.gastro.2016.01.032
Publication status	Published - 2016

Subject classification (UKÄ)

Gastroenterology and Hepatology

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10.1053/j.gastro.2016.01.032

http://www.ncbi.nlm.nih.gov/pubmed/26850495?dopt=Abstract

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Mancina, R. M., Dongiovanni, P., Petta, S., Pingitore, P., Meroni, M., Rametta, R., Borén, J., Montalcini, T., Pujia, A., Wiklund, O., Hindy, G., Spagnuolo, R., Motta, B. M., Pipitone, R. M., Craxì, A., Fargion, S., Nobili, V., Käkelä, P., Kärjä, V., ... Romeo, S. (2016). The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent. Gastroenterology, 150(5), 1219-1230e6. https://doi.org/10.1053/j.gastro.2016.01.032

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title = "The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.",

abstract = "Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.",

author = "Mancina, {Rosellina Margherita} and Paola Dongiovanni and Salvatore Petta and Piero Pingitore and Marica Meroni and Raffaela Rametta and Jan Bor{\'e}n and Tiziana Montalcini and Arturo Pujia and Olov Wiklund and George Hindy and Rocco Spagnuolo and Motta, {Benedetta Maria} and Pipitone, {Rosaria Maria} and Antonio Crax{\`i} and Silvia Fargion and Valerio Nobili and Pirjo K{\"a}kel{\"a} and Vesa K{\"a}rj{\"a} and Ville M{\"a}nnist{\"o} and Jussi Pihlajam{\"a}ki and Reilly, {Dermot F} and Jose Castro-Perez and Julia Kozlitina and Luca Valenti and Stefano Romeo",

year = "2016",

doi = "10.1053/j.gastro.2016.01.032",

language = "English",

volume = "150",

pages = "1219--1230e6",

journal = "Gastroenterology",

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Mancina, RM, Dongiovanni, P, Petta, S, Pingitore, P, Meroni, M, Rametta, R, Borén, J, Montalcini, T, Pujia, A, Wiklund, O, Hindy, G, Spagnuolo, R, Motta, BM, Pipitone, RM, Craxì, A, Fargion, S, Nobili, V, Käkelä, P, Kärjä, V, Männistö, V, Pihlajamäki, J, Reilly, DF, Castro-Perez, J, Kozlitina, J, Valenti, L & Romeo, S 2016, 'The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.', Gastroenterology, vol. 150, no. 5, pp. 1219-1230e6. https://doi.org/10.1053/j.gastro.2016.01.032

TY - JOUR

T1 - The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

AU - Mancina, Rosellina Margherita

AU - Dongiovanni, Paola

AU - Petta, Salvatore

AU - Pingitore, Piero

AU - Meroni, Marica

AU - Rametta, Raffaela

AU - Borén, Jan

AU - Montalcini, Tiziana

AU - Pujia, Arturo

AU - Wiklund, Olov

AU - Hindy, George

AU - Spagnuolo, Rocco

AU - Motta, Benedetta Maria

AU - Pipitone, Rosaria Maria

AU - Craxì, Antonio

AU - Fargion, Silvia

AU - Nobili, Valerio

AU - Käkelä, Pirjo

AU - Kärjä, Vesa

AU - Männistö, Ville

AU - Pihlajamäki, Jussi

AU - Reilly, Dermot F

AU - Castro-Perez, Jose

AU - Kozlitina, Julia

AU - Valenti, Luca

AU - Romeo, Stefano

PY - 2016

Y1 - 2016

N2 - Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.

AB - Nonalcoholic fatty liver disease (NAFLD) is a leading cause of liver damage and is characterized by steatosis. Genetic factors increase risk for progressive NAFLD. A genome-wide association study showed that the rs641738 C>T variant in the locus that contains the membrane bound O-acyltransferase domain-containing 7 gene (MBOAT7, also called LPIAT1) and transmembrane channel-like 4 gene (TMC4) increased the risk for cirrhosis in alcohol abusers. We investigated whether the MBOAT7-TMC4 is a susceptibility locus for the development and progression of NAFLD.

U2 - 10.1053/j.gastro.2016.01.032

DO - 10.1053/j.gastro.2016.01.032

M3 - Article

C2 - 26850495

SN - 1528-0012

VL - 150

SP - 1219-1230e6

JO - Gastroenterology

JF - Gastroenterology

IS - 5

ER -

The MBOAT7-TMC4 Variant rs641738 Increases Risk of Nonalcoholic Fatty Liver Disease in Individuals of European Descent.

Abstract

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