The mechanism of protein kinase C regulation

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Abstract

Protein kinase C (PKC) is a family of serine/threonine protein kinases that plays a central role in transducing extracellular signals into a variety of intracellular responses ranging from cell proliferation to apoptosis. Nine PKC genes have been identified in the human genome, which encode 10 proteins. Each member of this protein kinase family displays distinct biochemical characteristics and is enriched in different cellular and subcellular locations. Activation of PKC has been implicated in the regulation of cell growth and differentiation. This review summarizes works of the past years in the field of PKC biochemistry that covers regulation and activation mechanism of different PKC isoforms.
Original languageEnglish
Pages (from-to)328-336
JournalFrontiers in Biology
Volume6
Issue number4
Publication statusPublished - 2011
Externally publishedYes

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Experimental Clinical Chemistry (013016010)

Subject classification (UKÄ)

  • Medicinal Chemistry

Keywords

  • PKC biochemistry PKC kinase PKC phosphatases PKC structure

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