The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus

Christer Nilsson; Päivi Kannisto; Maria Lindvall-Axelsson; Christer Owman; Evald Rosengren

doi:10.1016/0014-2999(90)90085-K

The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus

Christer Nilsson, Päivi Kannisto, Maria Lindvall-Axelsson, Christer Owman, Evald Rosengren

Research output: Contribution to journal › Article › peer-review

Abstract

The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus.

Original language	English
Pages (from-to)	247-252
Journal	European Journal of Pharmacology
Volume	181
Issue number	3
DOIs	https://doi.org/10.1016/0014-2999(90)90085-K
Publication status	Published - 1990

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Department of Psychogeriatrics (013304000), Drug Target Discovery (013212045), Department of Experimental Medical Science (013210000)

Subject classification (UKÄ)

Pharmacology and Toxicology

Keywords

Presynaptic regulation
Sympathetic nerves
Choroid plexus
VIP (vasoactive intestinal polypeptide)
PHI (peptide histidine isoleucine)
Neuropeptide Y

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10.1016/0014-2999(90)90085-K

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@article{5b1168aa9fc54c0a86956013f636c2a6,

title = "The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus",

abstract = "The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus.",

keywords = "Presynaptic regulation, Sympathetic nerves, Choroid plexus, VIP (vasoactive intestinal polypeptide), PHI (peptide histidine isoleucine), Neuropeptide Y",

author = "Christer Nilsson and P{\"a}ivi Kannisto and Maria Lindvall-Axelsson and Christer Owman and Evald Rosengren",

note = "The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Department of Psychogeriatrics (013304000), Drug Target Discovery (013212045), Department of Experimental Medical Science (013210000)",

year = "1990",

doi = "10.1016/0014-2999(90)90085-K",

language = "English",

volume = "181",

pages = "247--252",

journal = "European Journal of Pharmacology",

issn = "1879-0712",

publisher = "Elsevier",

number = "3",

}

Nilsson, C, Kannisto, P, Lindvall-Axelsson, M, Owman, C & Rosengren, E 1990, 'The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus', European Journal of Pharmacology, vol. 181, no. 3, pp. 247-252. https://doi.org/10.1016/0014-2999(90)90085-K

The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus. / Nilsson, Christer; Kannisto, Päivi; Lindvall-Axelsson, Maria et al.

In: European Journal of Pharmacology, Vol. 181, No. 3, 1990, p. 247-252.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus

AU - Nilsson, Christer

AU - Kannisto, Päivi

AU - Lindvall-Axelsson, Maria

AU - Owman, Christer

AU - Rosengren, Evald

N1 - The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Department of Obstetrics and Gynaecology (Lund) (013018000), Department of Psychogeriatrics (013304000), Drug Target Discovery (013212045), Department of Experimental Medical Science (013210000)

PY - 1990

Y1 - 1990

N2 - The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus.

AB - The neurotransmitter peptides vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI) and neuropeptide Y (NPY) are located in nerve fibers supplying the pig choroid plexus, which receives an abundant sympathetic innervation. We characterized the release of [3H]noradrenaline ([3H]NA) from this tissue elicited by electrical field stimulation and studied the effects of the above-mentioned peptides on this release. The release of [3H]NA was found to be almost exclusively of neurogenic origin, despite there being a marked non-neuronal uptake of [3H]NA into the epithelium of the choroid plexus. NPY significantly decreased the release of [3H]NA by approximately 10% while VIP and PHI enhanced release by up to 25 and 35%, respectively, indicating a possible synergistic role of the two latter peptides and NA in the choroid plexus.

KW - Presynaptic regulation

KW - Sympathetic nerves

KW - Choroid plexus

KW - VIP (vasoactive intestinal polypeptide)

KW - PHI (peptide histidine isoleucine)

KW - Neuropeptide Y

U2 - 10.1016/0014-2999(90)90085-K

DO - 10.1016/0014-2999(90)90085-K

M3 - Article

SN - 1879-0712

VL - 181

SP - 247

EP - 252

JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 3

ER -

The neuropeptides vasoactive intestinal polypeptide, peptide histidine isoleucine and neuropeptide Y modulate [3H]noradrenaline release from sympathetic nerves in the choroid plexus

Abstract

Bibliographical note

Subject classification (UKÄ)

Keywords

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