The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders

Malin Hultqvist, Nandakumar Kutty Selva, U Bjorklund, Rikard Holmdahl

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives: Autoimmune diseases such as rheumatoid arthritis (RA) and multiple sclerosis (MS) affect a relatively large portion of the population, leading to severe disability if left untreated. Even though pharmaceutics targeting the immune system have revolutionised the therapy of these diseases, there is still a need for novel, more effective therapeutic substances. One such substance is the new chemical entity 9-chloro-2,3 dimethyl-6-(N, N-dimthylamino-2-oxoethyl)-6H-indolo [2,3-b] quionoxaline, Rabeximod, currently being investigated for efficiency in treatment of human RA. In this study we aimed to evaluate Rabeximod as a treatment for autoimmune diseases, using animal models. Methods: In the present investigation we have evaluated Rabeximod as a treatment for autoimmune diseases using mouse models of RA and MS, ie, collagen-induced arthritis, collagen antibody induced arthritis and experimental autoimmune encephalomyelitis. Results: Rabeximod efficiently prevented arthritis and encephalomyelitis in mice. In addition, this effect correlated to the timepoint when cells migrate into the joints. Conclusions: We conclude that Rabeximod reduces disease severity in animal models of autoimmunity and should be considered as a new therapeutic substance for MS and RA.
    Original languageEnglish
    Pages (from-to)130-135
    JournalAnnals of the Rheumatic Diseases
    Volume68
    Issue number1
    DOIs
    Publication statusPublished - 2009

    Bibliographical note

    The information about affiliations in this record was updated in December 2015.
    The record was previously connected to the following departments: Medical Inflammation Research (013212019)

    Subject classification (UKÄ)

    • Rheumatology and Autoimmunity

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