The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family

T. Gutjahr; E. Frei; C. Spicer; S. Baumgartner; R. A.H. White; M. Noll

doi:10.1002/j.1460-2075.1995.tb00104.x

The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family

T. Gutjahr, E. Frei, C. Spicer, S. Baumgartner, R. A.H. White, M. Noll

University of Zurich

Research output: Contribution to journal › Article › peer-review

Abstract

We have delimited the extra sex combs (esc) gene to <4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.

Original language	English
Pages (from-to)	4296-4306
Journal	EMBO Journal
Volume	14
Issue number	17
DOIs	https://doi.org/10.1002/j.1460-2075.1995.tb00104.x
Publication status	Published - 1995 Jan 1
Externally published	Yes

Free keywords

Extra sex combs
Gene silencing
Homeosis
Polycomb group
WD-40 repeat

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10.1002/j.1460-2075.1995.tb00104.x

Cite this

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title = "The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family",

abstract = "We have delimited the extra sex combs (esc) gene to <4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.",

keywords = "Extra sex combs, Gene silencing, Homeosis, Polycomb group, WD-40 repeat",

author = "T. Gutjahr and E. Frei and C. Spicer and S. Baumgartner and White, {R. A.H.} and M. Noll",

year = "1995",

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doi = "10.1002/j.1460-2075.1995.tb00104.x",

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TY - JOUR

T1 - The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family

AU - Gutjahr, T.

AU - Frei, E.

AU - Spicer, C.

AU - Baumgartner, S.

AU - White, R. A.H.

AU - Noll, M.

PY - 1995/1/1

Y1 - 1995/1/1

N2 - We have delimited the extra sex combs (esc) gene to <4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.

AB - We have delimited the extra sex combs (esc) gene to <4 kb that include a single transcript and are able to rescue both the maternal and zygotic esc phenotypes. Several mutations have been identified within the esc transcript. In agreement with earlier genetic studies, esc is expressed maternally and its product is most abundant during the early embryonic stages. It encodes a protein of the WD-40 repeat family, which localizes predominantly to the nucleus. During germ band extension, it is expressed in a stereotypic pattern of neuroblasts. We propose a model in which Esc is recruited by gap proteins both to act as a corepressor that competes with the TAF(II)80 coactivator to block transcription and also to mediate the transition to permanent repression by Polycomb-group proteins.

KW - Extra sex combs

KW - Gene silencing

KW - Homeosis

KW - Polycomb group

KW - WD-40 repeat

U2 - 10.1002/j.1460-2075.1995.tb00104.x

DO - 10.1002/j.1460-2075.1995.tb00104.x

M3 - Article

C2 - 7556071

AN - SCOPUS:0029122551

SN - 0261-4189

VL - 14

SP - 4296

EP - 4306

JO - EMBO Journal

JF - EMBO Journal

IS - 17

ER -

The Polycomb-group gene, extra sex combs, encodes a nuclear member of the WD-40 repeat family

Abstract

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