The prevalence of having coeliac disease in children with type 1 diabetes was not significantly higher during the Swedish coeliac epidemic

Mara Cerqueiro Bybrant, Elsa Palmkvist, Hanna Söderström, Marie Lindgren, Hans Hildebrand, Fredrik Norström, Annelie Carlsson

Research output: Contribution to journalArticlepeer-review

Abstract

Aim: From 1986 to 1996, there was a four-fold increase in coeliac disease among young Swedish children, known as the Swedish coeliac epidemic. Children with type 1 diabetes have an increased risk of developing coeliac disease. We studied whether the prevalence of coeliac disease differed in children with type 1 diabetes born during and after this epidemic. Methods: We compared national birth cohorts of 240 844 children born in 1992–1993 during the coeliac disease epidemic and 179 530 children born in 1997–1998 after the epidemic. Children diagnosed with both type 1 diabetes and coeliac disease were identified by merging information from five national registers. Results: There was no statistically significant difference in the prevalence of coeliac disease among children with type 1 diabetes between the two cohorts: 176/1642 (10.7%, 95% confidence interval 9.2%–12.2%) in the cohort born during the coeliac disease epidemic versus 161/1380 (11.7%, 95% confidence interval 10.0%–13.5%) in the post-epidemic cohort. Conclusion: The prevalence of having both coeliac disease and type 1 diabetes was not significantly higher in children born during, than after, the Swedish coeliac epidemic. This may support a stronger genetic disposition in children who develop both conditions.

Original languageEnglish
Pages (from-to)2175-2181
Number of pages7
JournalActa Paediatrica, International Journal of Paediatrics
Volume112
Issue number10
DOIs
Publication statusPublished - 2023 Oct

Subject classification (UKÄ)

  • Pediatrics

Free keywords

  • children and adolescents
  • coeliac disease12
  • epidemiology
  • register study
  • type 1 diabetes

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