The stability of AQT processing speed, ADAS-Cog and MMSE during acetylcholinesterase inhibitor treatment in Alzheimer's disease

E. H. Wiig, P. Annas, H. Basun, N. Andreasen, L. Lannfelt, H. Zetterberg, K. Blennow, Lennart Minthon

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives - To explore the longitudinal stability of measures of cognition during treatment with acetylcholinesterase inhibitors (AchEI) in patients with Alzheimer's disease (AD). Materials and methods -Cognitive status was measured in a cohort of 60 patients at 6 months after initiation of treatment with AchEI (baseline) and after an additional 6 months of treatment (endpoint). A Quick Test of Cognitive Speed (AQT), Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog), and MMSE were administered concurrently. Results-Correlations (rho) between age and AQT processing speed were non-significant, but were significant for ADAS-Cog and Mini Mental State Examination (MMSE). AQT and ADAS-Cog means did not differ significantly between baseline and endpoint. There was a small, significant reduction in MMSE point scores. Measures of stability (Spearman's rho) were moderate-to-high for all tests. Means for subgroups did not differ as a function of medication type. Conclusions - AQT processing speed, ADAS-Cog, and MMSE measures proved stable during the second 6 months of treatment with AChEI.
Original languageEnglish
Pages (from-to)186-193
JournalActa Neurologica Scandinavica
Volume121
Issue number3
DOIs
Publication statusPublished - 2010

Subject classification (UKÄ)

  • Neurology

Free keywords

  • treatment
  • AchEI
  • Alzheimer's disease
  • MMSE
  • ADAS-Cog
  • AQT
  • processing speed
  • longitudinal stability

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