The stratum corneum barrier – From molecular scale to macroscopic properties

Emma Sparr; Sebastian Björklund; Q. Dat Pham; Enamul H. Mojumdar; B. Stenqvist; M. Gunnarsson; D. Topgaard

doi:10.1016/j.cocis.2023.101725

The stratum corneum barrier – From molecular scale to macroscopic properties

Emma Sparr, Sebastian Björklund, Q. Dat Pham, Enamul H. Mojumdar, B. Stenqvist, M. Gunnarsson, D. Topgaard

Research output: Contribution to journal › Review article › peer-review

Abstract

The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.

Original language	English
Article number	101725
Journal	Current Opinion in Colloid and Interface Science
Volume	67
DOIs	https://doi.org/10.1016/j.cocis.2023.101725
Publication status	Published - 2023

Subject classification (UKÄ)

Physical Chemistry

Free keywords

Fluid and solid lipids
Heterogenous structures
Keratin filaments
Natural moisturizing factor
Skin hydration
Transport routes

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10.1016/j.cocis.2023.101725Licence: CC BY

Cite this

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title = "The stratum corneum barrier – From molecular scale to macroscopic properties",

abstract = "The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.",

keywords = "Fluid and solid lipids, Heterogenous structures, Keratin filaments, Natural moisturizing factor, Skin hydration, Transport routes",

author = "Emma Sparr and Sebastian Bj{\"o}rklund and Pham, {Q. Dat} and Mojumdar, {Enamul H.} and B. Stenqvist and M. Gunnarsson and D. Topgaard",

year = "2023",

doi = "10.1016/j.cocis.2023.101725",

language = "English",

volume = "67",

journal = "Current Opinion in Colloid and Interface Science",

issn = "1359-0294",

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TY - JOUR

T1 - The stratum corneum barrier – From molecular scale to macroscopic properties

AU - Sparr, Emma

AU - Björklund, Sebastian

AU - Pham, Q. Dat

AU - Mojumdar, Enamul H.

AU - Stenqvist, B.

AU - Gunnarsson, M.

AU - Topgaard, D.

PY - 2023

Y1 - 2023

N2 - The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.

AB - The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the different SC substructures are organized with respect to each other, including effects of non-equilibrium conditions in the skin with respect to the gradients in water and other components.

KW - Fluid and solid lipids

KW - Heterogenous structures

KW - Keratin filaments

KW - Natural moisturizing factor

KW - Skin hydration

KW - Transport routes

U2 - 10.1016/j.cocis.2023.101725

DO - 10.1016/j.cocis.2023.101725

M3 - Review article

AN - SCOPUS:85167567586

SN - 1359-0294

VL - 67

JO - Current Opinion in Colloid and Interface Science

JF - Current Opinion in Colloid and Interface Science

M1 - 101725

ER -

The stratum corneum barrier – From molecular scale to macroscopic properties

Abstract

Subject classification (UKÄ)

Free keywords

Access to Document

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Cite this