The Structure and Classification of Botulinum Toxins

Min Dong, Pål Stenmark

Research output: Chapter in Book/Report/Conference proceedingBook chapterpeer-review

6 Citations (SciVal)

Abstract

Botulinum neurotoxins (BoNTs) are a family of bacterial protein toxins produced by various Clostridium species. They are traditionally classified into seven major serotypes (BoNT/A-G). Recent progress in sequencing microbial genomes has led to an ever-growing number of subtypes, chimeric toxins, BoNT-like toxins, and remotely related BoNT homologs, constituting an expanding BoNT superfamily. Recent structural studies of BoNTs, BoNT progenitor toxin complexes, tetanus neurotoxin (TeNT), toxin-receptor complexes, and toxin-substrate complexes have provided mechanistic understandings of toxin functions and the molecular basis for their variations. The growing BoNT superfamily of toxins present a natural repertoire that can be explored to develop novel therapeutic toxins, and the structural understanding of their variations provides a knowledge basis for engineering toxins to improve therapeutic efficacy and expand their clinical applications.

Original languageEnglish
Title of host publicationBotulinum Toxin Therapy
EditorsScott M. Whitcup, Mark Hallett
PublisherSpringer Nature
Pages11-33
Number of pages23
Volume263
ISBN (Print)978-3-030-66305-6
DOIs
Publication statusPublished - 2021

Publication series

NameHandbook of experimental pharmacology
Volume263
ISSN (Print)0171-2004

Subject classification (UKÄ)

  • Medicinal Chemistry

Fingerprint

Dive into the research topics of 'The Structure and Classification of Botulinum Toxins'. Together they form a unique fingerprint.

Cite this