The synthesis of bicyclo[2.2.2]octan-2,6-dione revisited

Magnus Widegren, Melanie Dietz, Annika Friberg, Torbjörn Frejd, Bärbel Hahn-Hägerdal, Marie-Francoise Gorwa-Grauslund, Mikael Katz

Research output: Contribution to journalArticlepeer-review

10 Citations (SciVal)


The cyclisation conditions for the formation of bicyclo[2.2.2]octan-2,6-di one (1) from 3-substituted cyclohexanones 2 and 3 have been re-investigated. Use of a medium consisting of isobutyric anhydride and trifluoroacetic acid resulted in a simplified and reproducible method for large-scale synthesis of this compound.
Original languageEnglish
Pages (from-to)3527-3530
Issue number20
Publication statusPublished - 2006

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Organic chemistry (S/LTH) (011001240), Applied Microbiology (LTH) (011001021), Department of Chemistry (011001220)

Subject classification (UKÄ)

  • Organic Chemistry
  • Industrial Biotechnology


  • carboxylic acids
  • diketones
  • bicyclic compounds
  • cyclisations
  • anhydrides


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