The use of holographic interferometry and electron speckle pattern interferometry for diffusion measurement in biochemical and pharmaceutical engineering applications

Anders Axelsson, Mariagrazia Marucci

Research output: Contribution to journalArticlepeer-review

Abstract

In this review holographic interferometry and electron speckle pattern interferometry are discussed as efficient techniques for diffusion measurements in biochemical and pharmaceutical applications. Transport phenomena can be studied, quantitatively and qualitatively, in gels, liquids and membranes. Detailed information on these phenomena is required to design effective chromatography bioseparation processes using gel beads or ultrafiltration membranes, and in the design of control led-release pharmaceuticals using membrane-coated pellets or tablets. The influence of gel concentration, ion strength in the liquid and the size of diffusing protein molecules can easily be studied with good accuracy. When studying membranes, the resistance can be quantified, and it is also possible to discriminate between permeable and semi-permeable membranes. In this review the influence of temperature, natural convection and light deflection on the accuracy of the diffusion measurements is also discussed. (c) 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)865-876
JournalOptics and Lasers in Engineering
Volume46
Issue number12
DOIs
Publication statusPublished - 2008

Subject classification (UKÄ)

  • Chemical Engineering

Free keywords

  • Pharmaceutical
  • Protein
  • Membrane
  • Gel
  • Diffusion
  • ESPI
  • Holographic laser interferometry
  • Bioseparation
  • Osmosis

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