The Value of Induction Chemotherapy for Survival in Patients with Non-small Cell Lung Cancer Treated with Radiotherapy

Georg Holgersson, Martin Sandelin, Even Hoye, Stefan Bergstrom, Roger Henriksson, Simon Ekman, Jan Nyman, Martin Helsing, Signe Friesland, Ola Brodin, Margareta Holgersson, Kristina Lamberg Lundstrom, Christer Janson, Lars Ekberg, Charlotte Morth, Thomas Blystad, Sven-Börje Ewers, Britta Loden, Michael Bergqvist

Research output: Contribution to journalArticlepeer-review

1 Citation (SciVal)

Abstract

Aim: The aim of the present study was to retrospectively investigate the impact of induction chemotherapy on treatment outcome in patients treated with curatively intended radiotherapy for non-small cell lung cancer (NSCLC). Patients and Methods: Patients with a diagnosed NSCLC that have been subjected to curatively intended irradiation (>= 50 Gy) and treated in an oncology department in Sweden during the years 1990-2000 were included in the study. Operated patients and patients having received concomitant chemotherapy were excluded. The included patients were localised by a manual search of all the oncology departments' medical records and radiation charts. Results: Patients treated with induction chemotherapy (n=79) had a significantly better overall survival compared with patients treated with radiotherapy alone (p=0.0097) in a univariate Cox regression analysis. A platinum/taxane combination produced the greatest survival benefit; hazard ratio=0.49 (95% confidence interval=0.31 to 0.75). Conclusion: We found that patients treated with induction chemotherapy in addition to radiotherapy for NSCLC have a better overall survival than patients treated with radiotherapy alone and that the best results are achieved using a platinum/taxane combination.
Original languageEnglish
Pages (from-to)1339-1346
JournalAnticancer research
Volume32
Issue number4
Publication statusPublished - 2012

Subject classification (UKÄ)

  • Cancer and Oncology

Keywords

  • NSCLC
  • lung cancer
  • radiotherapy
  • predictive value
  • age

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