Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme

Karin Holm; Mattias Collin; Lena Hagelskjær-Kristensen; Anders Jensen; Magnus Rasmussen

doi:10.1016/j.anaerobe.2017.03.016

Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme

Karin Holm, Mattias Collin, Lena Hagelskjær-Kristensen, Anders Jensen, Magnus Rasmussen

Research output: Contribution to journal › Article › peer-review

Abstract

Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.

Original language	English
Pages (from-to)	129-132
Journal	Anaerobe
Volume	45
Early online date	2017 Mar 19
DOIs	https://doi.org/10.1016/j.anaerobe.2017.03.016
Publication status	Published - 2017

Subject classification (UKÄ)

Microbiology in the medical area

Free keywords

Fusobacterium necrophorum
Lemierre
Leukocidin
Leukotoxin
Pharyngotonsillitis
Sequencing

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10.1016/j.anaerobe.2017.03.016

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abstract = "Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.",

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author = "Karin Holm and Mattias Collin and Lena Hagelskj{\ae}r-Kristensen and Anders Jensen and Magnus Rasmussen",

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AU - Holm, Karin

AU - Collin, Mattias

AU - Hagelskjær-Kristensen, Lena

AU - Jensen, Anders

AU - Rasmussen, Magnus

PY - 2017

Y1 - 2017

N2 - Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.

AB - Leukotoxin is a well-known virulence factor of animal isolates of Fusobacterium necrophorum subspecies necrophorum, and is also expressed by animal isolates of subspecies funduliforme, whereas its presence in isolates from humans has not been fully established. In this study we found that the leukotoxin gene was present in all tested F. necrophorum isolates from humans. Three sequence variants were found, two of which have not been described previously. The sequence types correlated to source of infection. Further studies are needed to examine the role of the leukotoxin in human infections.

KW - Fusobacterium necrophorum

KW - Lemierre

KW - Leukocidin

KW - Leukotoxin

KW - Pharyngotonsillitis

KW - Sequencing

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DO - 10.1016/j.anaerobe.2017.03.016

M3 - Article

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AN - SCOPUS:85016519093

SN - 1075-9964

VL - 45

SP - 129

EP - 132

JO - Anaerobe

JF - Anaerobe

ER -

Three variants of the leukotoxin gene in human isolates of Fusobacterium necrophorum subspecies funduliforme

Abstract

Subject classification (UKÄ)

Free keywords

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