Thrombotic microangiopathy mimicking membranoproliferative glomerulonephritis

Damien Brackman, Lisa Sartz, Sabine Leh, Ann-Charlotte Kristoffersson, Anna Bjerre, Ramesh Tati, Veronique Fremeaux-Bacchi, Diana Karpman

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Abstract

A 4-year-old boy presented with proteinuria and developed progressive renal failure over 6 years. In the patient's family, five individuals were affected with atypical haemolytic uraemic syndrome (aHUS) but not the patient. Renal biopsies (n = 3) showed glomerular basement membrane thickening with double contours, endothelial swelling and deposits of C3 and C1q. Electron microscopy revealed mesangial and subendothelial electron-dense deposits. Complement mutations in membrane cofactor protein (Y155D) and C3 (R713W and G1094R) were detected in all affected family members. The patient also had transient autoantibodies to factor H. The findings suggest that aHUS and glomerulopathy resembling membranoproliferative glomerulonephritis may have a common molecular background.
Original languageEnglish
Pages (from-to)3399-3403
JournalNephrology Dialysis Transplantation
Volume26
Issue number10
DOIs
Publication statusPublished - 2011

Subject classification (UKÄ)

  • Urology and Nephrology

Keywords

  • complement
  • C3
  • haemolytic uraemic syndrome
  • membranoproliferative
  • glomerulonephritis
  • eculizumab

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