Thymic-derived tolerizing dendritic cells are upregulated in the spleen upon treatment with intravenous immunoglobulin in a murine model of immune thrombocytopenia AU - Kapur, Rick

Rukhsana Aslam, Michael Kim, Li Guo, Heyu Ni, George B. Segel, John W. Semple

Research output: Contribution to journalLetterpeer-review

Abstract

AbstractImmune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by low platelet counts. First-line treatment includes intravenous immunoglobulin (IVIg), however, its working mechanism remains incompletely understood. We investigated splenic and thymic dendritic cell (DC) subsets upon IVIg treatment in a well-characterized active murine model of ITP. During active disease, there was a significant peripheral deficiency of splenic tolerizing SIRPα+ DCs which could be rescued by IVIg therapy, increasing platelet counts. These splenic tolerizing DC changes were associated with an abrogation of the thymic-retention of tolerizing DCs, suggesting that IVIg may raise platelet counts in ITP by modulating peripheral numbers of tolerizing DCs.
Original languageEnglish
Pages (from-to)521-524
JournalPlatelets
Volume28
Issue number5
DOIs
Publication statusPublished - 2017 Jul 4
Externally publishedYes

Bibliographical note

doi: 10.1080/09537104.2016.1246718

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