Thymidine kinase diversity in bacteria

Michael Sandrini; Anders Ranegaard Clausen; Birgitte Munch-Petersen; Jure Piskur

doi:10.1080/15257770600894469

Thymidine kinase diversity in bacteria

Michael Sandrini, Anders Ranegaard Clausen, Birgitte Munch-Petersen, Jure Piskur

Department of Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

Original language	English
Pages (from-to)	1153-1158
Journal	Nucleosides, Nucleotides & Nucleic Acids
Volume	25
Issue number	9-11
DOIs	https://doi.org/10.1080/15257770600894469
Publication status	Published - 2006

Subject classification (UKÄ)

Biological Sciences

Free keywords

pyrimidines
nucleosides
thymidine kinase
deoxyribonucleoside kinase
evolution
nucleic acids precursors

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1080/15257770600894469

Cite this

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title = "Thymidine kinase diversity in bacteria",

abstract = "Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.",

keywords = "pyrimidines, nucleosides, thymidine kinase, deoxyribonucleoside kinase, evolution, nucleic acids precursors",

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AU - Sandrini, Michael

AU - Clausen, Anders Ranegaard

AU - Munch-Petersen, Birgitte

AU - Piskur, Jure

PY - 2006

Y1 - 2006

N2 - Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

AB - Thymidine kinases (TKs) appear to be almost ubiquitous and are found in nearly all prokaryotes, eukaryotes, and several viruses. They are the key enzymes in thymidine salvage and activation of several anti-cancer and antiviral drugs. We show that bacterial TKs can be subdivided into 2 groups. The TKs from Gram-positive bacteria are more closely related to the eukaryotic TK1 enzymes than are TKs from Gram-negative bacteria.

KW - pyrimidines

KW - nucleosides

KW - thymidine kinase

KW - deoxyribonucleoside kinase

KW - evolution

KW - nucleic acids precursors

U2 - 10.1080/15257770600894469

DO - 10.1080/15257770600894469

M3 - Article

SN - 1525-7770

VL - 25

SP - 1153

EP - 1158

JO - Nucleosides, Nucleotides & Nucleic Acids

JF - Nucleosides, Nucleotides & Nucleic Acids

IS - 9-11

ER -

Thymidine kinase diversity in bacteria

Abstract

Subject classification (UKÄ)

Free keywords

UN SDGs

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