Tissue reactions to polyethylene implants with different surface topography

Agneta Rosengren, Lars Magnus Bjursten, Nils Danielsen, H Persson, M Kober

Research output: Contribution to journalArticlepeer-review


This study investigates the importance of implant surface topography on soft tissue response. The tissue response in the rat abdominal wall to discs of low density polyethylene with smooth to coarse surfaces was evaluated after one, six or 12 weeks. Capsule thickness and immunohistochemical quantification of monocytes-macrophages were used as measures. The macrophage specific antibody ED1 was used for identification of newly recruited macrophages and the ED2 antibody for the mature tissue macrophages. The smoother surfaces gave a thicker capsule than the rougher surfaces, and at one week also larger total numbers of cells and ED1 positive macrophages at interface. The capsule thickness increased over time for the smooth and intermediate surface topographies. In contrast, the cell numbers generally decreased over time. In conclusion, a coarse surface elicited lesser tissue reaction compared with a smooth surface.
Original languageEnglish
Pages (from-to)75-82
JournalJournal of Materials Science: Materials in Medicine
Issue number2
Publication statusPublished - 1999

Bibliographical note

The information about affiliations in this record was updated in December 2015.
The record was previously connected to the following departments: Bioimplant Research (013242910), Neural Interfaces (013212003), Chemical Engineering (011001014)

Subject classification (UKÄ)

  • Medical Materials


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