TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Kaspar Russ; Gabriel Teku; Luc Bousset; Virginie Redeker; Sara Piel; Ekaterina Savchenko; Yuriy Pomeshchik; Jimmy Savistchenko; Tina C. Stummann; Carla Azevedo; Anna Collin; Stefano Goldwurm; Karina Fog; Eskil Elmer; Mauno Vihinen; Ronald Melki; Laurent Roybon

doi:10.1016/j.celrep.2021.108895

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon

Research output: Contribution to journal › Article › peer-review

Abstract

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

Original language	English
Article number	108895
Journal	Cell Reports
Volume	34
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2021.108895
Publication status	Published - 2021

Subject classification (UKÄ)

Cell and Molecular Biology

Free keywords

alpha-synuclein
astrocytes
HLA genes
iPSC
Parkinson's disease
reactivity

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10.1016/j.celrep.2021.108895

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Russ, K., Teku, G., Bousset, L., Redeker, V., Piel, S., Savchenko, E., Pomeshchik, Y., Savistchenko, J., Stummann, T. C., Azevedo, C., Collin, A., Goldwurm, S., Fog, K., Elmer, E., Vihinen, M., Melki, R., & Roybon, L. (2021). TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration. Cell Reports, 34(12), Article 108895. https://doi.org/10.1016/j.celrep.2021.108895

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title = "TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration",

abstract = "Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.",

keywords = "alpha-synuclein, astrocytes, HLA genes, iPSC, Parkinson's disease, reactivity",

author = "Kaspar Russ and Gabriel Teku and Luc Bousset and Virginie Redeker and Sara Piel and Ekaterina Savchenko and Yuriy Pomeshchik and Jimmy Savistchenko and Stummann, {Tina C.} and Carla Azevedo and Anna Collin and Stefano Goldwurm and Karina Fog and Eskil Elmer and Mauno Vihinen and Ronald Melki and Laurent Roybon",

year = "2021",

doi = "10.1016/j.celrep.2021.108895",

language = "English",

volume = "34",

journal = "Cell Reports",

issn = "2211-1247",

publisher = "Cell Press",

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Russ, K, Teku, G, Bousset, L, Redeker, V, Piel, S , Savchenko, E , Pomeshchik, Y, Savistchenko, J, Stummann, TC, Azevedo, C, Collin, A, Goldwurm, S, Fog, K, Elmer, E , Vihinen, M, Melki, R & Roybon, L 2021, 'TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration', Cell Reports, vol. 34, no. 12, 108895. https://doi.org/10.1016/j.celrep.2021.108895

TY - JOUR

T1 - TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

AU - Russ, Kaspar

AU - Teku, Gabriel

AU - Bousset, Luc

AU - Redeker, Virginie

AU - Piel, Sara

AU - Savchenko, Ekaterina

AU - Pomeshchik, Yuriy

AU - Savistchenko, Jimmy

AU - Stummann, Tina C.

AU - Azevedo, Carla

AU - Collin, Anna

AU - Goldwurm, Stefano

AU - Fog, Karina

AU - Elmer, Eskil

AU - Vihinen, Mauno

AU - Melki, Ronald

AU - Roybon, Laurent

PY - 2021

Y1 - 2021

N2 - Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

AB - Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

KW - alpha-synuclein

KW - astrocytes

KW - HLA genes

KW - iPSC

KW - Parkinson's disease

KW - reactivity

U2 - 10.1016/j.celrep.2021.108895

DO - 10.1016/j.celrep.2021.108895

M3 - Article

C2 - 33761362

AN - SCOPUS:85103092287

SN - 2211-1247

VL - 34

JO - Cell Reports

JF - Cell Reports

IS - 12

M1 - 108895

ER -

TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Abstract

Subject classification (UKÄ)

Free keywords

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