TNF-α and α-synuclein fibrils differently regulate human astrocyte immune reactivity and impair mitochondrial respiration

Kaspar Russ, Gabriel Teku, Luc Bousset, Virginie Redeker, Sara Piel, Ekaterina Savchenko, Yuriy Pomeshchik, Jimmy Savistchenko, Tina C. Stummann, Carla Azevedo, Anna Collin, Stefano Goldwurm, Karina Fog, Eskil Elmer, Mauno Vihinen, Ronald Melki, Laurent Roybon

Research output: Contribution to journalArticlepeer-review

Abstract

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

Original languageEnglish
Article number108895
JournalCell Reports
Volume34
Issue number12
DOIs
Publication statusPublished - 2021

Subject classification (UKÄ)

  • Cell and Molecular Biology

Keywords

  • alpha-synuclein
  • astrocytes
  • HLA genes
  • iPSC
  • Parkinson's disease
  • reactivity

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