Abstract
Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.
Original language | English |
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Article number | 108895 |
Journal | Cell Reports |
Volume | 34 |
Issue number | 12 |
DOIs | |
Publication status | Published - 2021 |
Subject classification (UKÄ)
- Cell and Molecular Biology
Free keywords
- alpha-synuclein
- astrocytes
- HLA genes
- iPSC
- Parkinson's disease
- reactivity